|
Adverse events reported |
|||
| Adverse Event |
Niacin (n = 33) |
Placebo (n = 35) |
P-value |
|
|
|||
| Composite of pruritus (head. neck, extremities or torso): |
25 (75%) |
0 |
<0.001 |
| Composite of tingling (head, torso): |
10 (30%) |
0 |
<0.001 |
| Unpleasant warmth or flushing: |
33 (100%) |
1 |
<0.001 |
| Nausea |
10 (30%) |
1 (3%) |
.005 |
| Vomiting |
4 (12%) |
0 |
.005 |
| Stomach cramps |
2 (6%) |
0 |
NS |
| Vertigo |
4 (12%) |
0 |
.05 |
| Difficult breathing |
2 (6%) |
0 |
NS |
| Chills* |
17 (52%) |
0 |
< .0001 |
| Pass stool |
3 (9%) |
0 |
NS |
| Heart palpitations |
5 (15%) |
0 |
.0228 |
| Other |
4 (12%) |
1 (3%) |
NS |
|
* Chills are defined as shivering accompanied by the sensation of coldness and pallor of the skin. | |||
Mills et al. BMC Clinical Pharmacology 2003 3:4 doi:10.1186/1472-6904-3-4 |
|||