Table 6 |
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|
Spreadsheat description of PBPK parameters for the 70 Kg, 20% fat "standardhuman". |
||||||||||||
|
Organ |
Weight (Kg) |
Lipid Fraction |
Solid Fraction |
Solid (Kg) |
ecf Fraction |
water (L) |
water /Kg |
ecf water(L) |
flow (L/Kg) |
flow (L/min) |
Ka |
Ka*ecf |
|
|
||||||||||||
|
Blood |
5.5 |
0 |
0.18 |
0.99 |
0.595 |
4.51 |
0.82 |
2.68345 |
||||
|
liver |
1.8 |
0 |
0.3 |
0.54 |
0.23 |
1.26 |
0.7 |
0.2898 |
0.25 |
0.45 |
0.5 |
0.1449 |
|
portal |
1.5 |
0 |
0.22 |
0.33 |
0.3 |
1.17 |
0.78 |
0.351 |
0.75 |
1.125 |
0.35 |
0.1228 |
|
muscle |
26 |
0 |
0.22 |
5.72 |
0.15 |
20.28 |
0.78 |
3.042 |
0.0225 |
0.585 |
0.5 |
1.521 |
|
kidney |
0.31 |
0 |
0.2 |
0.062 |
0.165 |
0.248 |
0.8 |
0.04092 |
4 |
1.24 |
0.35 |
0.0143 |
|
brain |
1.4 |
0 |
0.2 |
0.28 |
0 |
1.12 |
0.8 |
0 |
0.56 |
0.784 |
0.1 |
0 |
|
heart |
0.33 |
0 |
0.2 |
0.066 |
0.25 |
0.264 |
0.8 |
0.066 |
0.8 |
0.264 |
0.5 |
0.033 |
|
lung |
0.536 |
0 |
0.2 |
0.107 |
0.2 |
0.428 |
0.8 |
0.08576 |
10.482 |
5.6184 |
0.35 |
0.03 |
|
skin |
2.6 |
0 |
0.3 |
0.78 |
0.6 |
1.82 |
0.7 |
1.092 |
0.1 |
0.26 |
0.25 |
0.273 |
|
tendon |
3 |
0 |
0.15 |
0.45 |
1 |
2.55 |
0.85 |
2.55 |
0.01 |
0.03 |
0.25 |
0.6375 |
|
other |
5.524 |
0 |
0.15 |
0.828 |
0.8 |
4.695 |
0.85 |
3.75632 |
0.02 |
0.1104 |
0.25 |
0.9390 |
|
bone |
4 |
0 |
1 |
4 |
0.5 |
0 |
0 |
0 |
0 |
0 |
0 |
|
|
adipose |
17.5 |
0.8 |
0 |
0 |
1 |
3.5 |
0.2 |
3.5 |
0.044 |
0.77 |
0.35 |
1.225 |
|
|
||||||||||||
|
Total |
70 |
0.2 |
14.15 |
41.84 |
17.4572 |
5.6184 |
4.9406 |
|||||
|
|
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|
Levitt BMC Clinical Pharmacology 2003 3:3 doi:10.1186/1472-6904-3-3 |
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