Figure 9.

Evaluation of the "gamma distribution" deconvolution method for "noisy" data. The green line (left column) shows the gamma distribution intestinal input to the "binding" PBPK model. The PBPK model venous concentration produced by this input was made "noisy" by adding a normally distributed random error (black squares, right column) and these data points were then used to determined an intestinal input rate (black line) and the corresponding venous concentration (red line) using the gamma distribution deconvolution method. Each row shows the results for a different set of random data.