Table 2

Variety of mutations associated with RIF and INH resistance (sputum specimens)

Drug resistance patterns

No of strains resistant to relevant drug

%


RIF resistance pattern (rpoB gene)


WT probes

Mutant probes

N = 107


Δ8

S531L

93

86.9


Δ8

-

3

2.8


Δ7

H526Y

1

0.9


Δ7

H526D

1

0.9


Δ7,Δ8

-

3

2.8


Δ6

-

2

1.9


Δ3,Δ8

D516V, S531L

1

0.9


Δ3,Δ8

D516V

1

0.9


Δ2,Δ7

-

1

0.9


Δ2,Δ4

-

1

0.9


INH resistance pattern


katG

inhA


WT probes

Mutant probes

WT1 probe

WT2 probe

Mutant probes

N = 117


Δwt

S315T1

WT

WT

-

68

58.1


Δwt

S315T1

WT

WT

C15T

5

4.3


Δwt

S315T1

WT

Δwt

-

2

1.7


Δwt

S315T1

Δwt

WT

C15T

2

1.7


Δwt

S315T1

Δwt

WT

-

2

1.7


Δwt

S315T1, S315T2

WT

WT

-

1

0.9


WT

-

Δwt

WT

C15T

3

2.6


WT

-

WT

WT

C15T

1

0.9


WT

S315T1

WT

WT

-

11

9.4


WT

S315T1

WT

WT

C15T

16

13.7


WT

S315T1

WT

WT

A16G

1

0.9


WT

S315T1

WT

WT

C15T, A16G

3

2.6


WT

S315T1

WT

Δwt

-

1

0.9


WT

S315T1

Δwt

Δwt

-

1

0.9


Notes: ΔN (N = 2...8) – missing WT probe

WT – all WT probes are present

Δwt – missing WT probe(s)

Nikolayevskyy et al. BMC Clinical Pathology 2009 9:2   doi:10.1186/1472-6890-9-2

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