Open Access Case report

Morphologic and immunophenotypic evidence of in-situ Kaposi's sarcoma

Panagiotis A Konstantinopoulos1, Bruce J Dezube1* and Liron Pantanowitz2

Author affiliations

1 Department of Hematology/Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA

2 Department of Pathology, Baystate Medical Center, Tufts University School of Medicine, Springfield, Massachusetts, USA

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Citation and License

BMC Clinical Pathology 2006, 6:7  doi:10.1186/1472-6890-6-7

Published: 30 October 2006

Abstract

Background

The spectrum of Kaposi's sarcoma (KS) has been expanded to include pre-KS lesions.

Case Presentation

We report, for the first time, a case providing direct histological evidence of the development of early (in-situ) KS from mediastinal lymphatic vessels in the setting of chronic lymphedema in an HIV-positive patient. Spindle-shaped and endothelial cells in these early KS-appearing lesions were immunoreactive for HHV8, D2-40 and CD34.

Conclusion

Our findings suggest that HHV8-infected spindle-shaped cells associated with lymphangiogenesis that evolve into KS lesions, acquire from the outset an aberrant mixed vascular and lymphatic endothelial cell phenotype.