Morphologic and immunophenotypic evidence of in-situ Kaposi's sarcoma
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BMC Clinical Pathology 2006, 6:7 doi:10.1186/1472-6890-6-7Published: 30 October 2006
The spectrum of Kaposi's sarcoma (KS) has been expanded to include pre-KS lesions.
We report, for the first time, a case providing direct histological evidence of the development of early (in-situ) KS from mediastinal lymphatic vessels in the setting of chronic lymphedema in an HIV-positive patient. Spindle-shaped and endothelial cells in these early KS-appearing lesions were immunoreactive for HHV8, D2-40 and CD34.
Our findings suggest that HHV8-infected spindle-shaped cells associated with lymphangiogenesis that evolve into KS lesions, acquire from the outset an aberrant mixed vascular and lymphatic endothelial cell phenotype.