Table 3

miR-21 in tumor cells and stroma as predictors for disease-specific survival in NSCLC patients (univariate analysis; log-rank test) and results of Cox regression analysis summarizing significant independent prognostic factors
Characteristics Pts (n) Pts (%) Median survival (months) 5-Year survival (%) Univariate (P) Multi-variate (P) HR 95% CI
Total (n = 335) 0.45 0.71 1.08
 Low 220 66 190 61 0.73-1.60
 High 98 29 98 55
 Missing 17 5
Tumor1 (n = 335) 0.65 0.40 1.20
 Low 60 18 NR 59 0.74-1.95
 High 258 77 127 59
 Missing 17 5
  N0 (n = 223) 0.091 0.33 0.69
   Low 43 19 NR 75 0.33-1.45
   High 180 81 190 66
  N+ (n = 95) 0.024 0.027 2.03
   Low 17 18 17 18 1.09-3.78
   High 78 82 37 42
Stroma2 (n = 335) 0.022 0.12 0.45
 Low 21 6 189 89 0.16-1.24
 High 301 90 127 57
 Missing 13 4
  N0 (n = 225) 0.044 0.061 0.32
   Low 16 7 190 93 0.08-1.38
   High 209 93 NR 66
  N+ (n = 97) 0.44 0.45 0.58
   Low 5 5 71 75 0.14-2.37
   High 92 95 27 36

NR = not reached.

1Tumor cells.

2Cells of the peritumoral connective tissue (fibroblasts, mesenchymal cells, immune cells, endothelial cells, pericytes and extracellular matrix.

Statistically significant results in bold font.

Stenvold et al.

Stenvold et al. BMC Clinical Pathology 2014 14:9   doi:10.1186/1472-6890-14-9

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