Table 2

Angiogenic markers as predictors for disease-specific survival, metastasis and local recurrence in patients with resected soft-tissue sarcomas of the extremities or trunk (univariate analyses, log rank test, n = 115)
Disase-specific survival Metastasis-free survival Recurrence-free survival
Marker expression Patients (n) 5-Year survival (%) P 5-Year survival (%) P 5-Year survival (%) P
PDGF-A
Low 54 60 0.035 74 0.007 79 0.012
High 58 52 51 55
Missing 3
PDGF-B
Low 44 68 0.006 78 0.003 82 0.015
High 68 48 52 56
Missing 3
PDGF-C
Low 31 71 0.032 68 0.214 68 0.564
High 80 50 61 65
Missing 4
PDGF-D
Low 73 67 0.003 70 0.051 77 0.002
High 40 34 49 42
Missing 2
PDGFR-α
Low 69 67 0.002 74 0.002 77 0.011
High 43 38 42 45
Missing 3
PDGFR-β
Low 85 64 0.029 72 0.002 69 0.825
High 24 32 35 58
Missing 6
VEGF-A
Low 60 65 0.001 75 0.001 77 0.002
High 51 43 48 51
Missing 4
VEGF-C
Low 69 55 0.476 68 0.083 68 0.232
High 38 60 56 63
Missing 8
VEGF-D
Low 84 57 0.131 67 0.081 70 0.177
High 29 50 51 55
Missing 2
VEGFR-1
Low 67 63 0.002 77 <0.001 72 0.036
High 44 46 43 58
Missing 4
VEGFR-2
Low 78 58 0.332 67 0.189 71 0.240
High 28 52 53 57
Missing 9
VEGFR-3
Low 75 60 0.053 70 0.008 70 0.159
High 34 45 46 57
Missing 6
FGF2
Low 75 61 0.033 66 0.214 70 0.648
High 35 49 56 67
Missing 6
FGFR-1
Low 83 58 0.460 64 0.411 66 0.768
High 26 47 55 71
Missing 6

Abbreviations: PDGF Platelet-derived growth factor, PDGFR Platelet-derived growth factor receptor, VEGF Vascular endothelial growth factor, VEGFR Vascular endothelial growth factor receptor, FGF Fibroblast growth factor, FGFR Fibroblast growth factor receptor.

Kilvaer et al.

Kilvaer et al. BMC Clinical Pathology 2014 14:5   doi:10.1186/1472-6890-14-5

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