Table 3

Topmost five upstream regulators predicted for the 55 Upr I/U-DEGs unique to P.a. -infected wounds on POD6 in the categories Cytokine, G-protein-coupled receptor, Growth factor, Ligand-dependent nuclear receptor, and Transmembrane receptor
Upstream regulator Log ratio Activation z-score p-value of overlap Target molecules in dataset
TLR3 0.340 3.111 7.13E-19 CXCL10, DDX58, DHX58, GBP4, GCH1, IFIH1, IFIT1, IFIT3, IL15, IL23A, IRF7, STAT1, TLR3, TNFSF10, USP18, ZNFX1
IFN Beta 3.395 1.34E-16 CXCL10, IFIH1, IFIT1, IFIT1B, IL15, IRF7, STAT1, TAPBP, TLR3, TNFSF10, USP18, XAF1
Interferon alpha 3.913 1.67E-16 CXCL10, DDX58, DHX58, IFIH1, IFIT1, IFIT1B, IFIT3, IL15, IRF7, PRF1, STAT1, TAPBP, TLR3, TNFSF10, USP18, WARS
IFN type 1 2.087 3.44E-15 CXCL10, DDX58, DHX58, IFIH1, IFIT1, IFIT1B, STAT1, TNFSF10, UBA7
Ifn 2.793 4.54E-12 CXCL10, DDX58, DHX58, IFIH1, IFIT1, IL15, IRF7, STAT1, TLR3

Leung et al.

Leung et al. BMC Clinical Pathology 2014 14:20   doi:10.1186/1472-6890-14-20

Open Data