Open Access Research article

Dermal wound transcriptomic responses to Infection with Pseudomonas aeruginosa versus Klebsiella pneumoniae in a rabbit ear wound model

Kai P Leung1*, Peter D’Arpa12, Akhil K Seth3, Matthew R Geringer3, Marti Jett2, Wei Xu3, Seok J Hong3, Robert D Galiano3, Tsute Chen4 and Thomas A Mustoe3

Author Affiliations

1 Microbiology Branch, US Army Dental and Trauma Research Detachment, Institute of Surgical Research, 3650 Chambers Pass, Building 3610, JBSA Fort Sam Houston, TX 78234, USA

2 Systems and Integrative Biology, US Army Center for Environmental Health Research, Fort Detrick, Frederick, MD, USA

3 Division of Plastic Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA

4 The Forsyth Dental Institute, 245 First Street, Cambridge, MA 02142, USA

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BMC Clinical Pathology 2014, 14:20  doi:10.1186/1472-6890-14-20

Published: 2 May 2014

Additional files

Additional file 1:

List of gene probes and associated normalized log2 fold-changes and adjusted p-values.

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Additional file 2:

Genes upregulated to a greater extent in K.p.-infected wounds on POD4.

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Additional file 3:

Upstream regulators and the 56 downstream molecules unique to P.a.-infected wounds they are inferred to regulate on POD4.

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Additional file 4:

Regulatory network of P.a.-infected wounds on POD6.

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Additional file 5:

Transcripts elevated in P.a.- relative to K.p.-infected wounds on POD12.

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Additional file 6:

86 transcripts elevated in K.p.- relative to P.a.-infected wounds on POD12.

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Additional file 7: Table S1:

RT-qPCR validation of microarray gene expression.

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