Table 3

Diagnostic performance of the different tests employed in the diagnosis of suspicious metastatic cervical lymph nodes (CLN) from thyroid cancer patients
Test Sensitivity Specificity PPV NPV Accuracy
PTC + ATC CLN (n = 29)
FNAB-C 88.5 (23/26) [69.9-97.6] N.D. (0/0) [N.D.] 100 (23/23) [85.2-100] N.D. (0/3) [0-70.8] 88.5 (23/26) [69.9-97.6]
FNAB-Tgp 92.3 (24/26) [74.9-99.1] N.D. (0/0) [N.D.] 100 (24/24) [85.8-100] N.D. (0/2) [0-84.2] 92.3 (24/26) [74.9-99.1]
FNAB-Tgm 87.5 (21/24) [88.1-100] N.D. (0/0) [N.D.] 100 (21/21) [84.0-100] N.D. (0/3) [0-70.8] 87.5 (21/24) [88.1-100]
FNAB-Tgp + -Tgm 100 (29/29) [88.1-100] N.D. (0/0) [N.D.] 100 (29/29) [88.1-100] N.D. (0/0) [N.D.] 100 (29/29) [88.1-100]
FNAB-C + -Tgp 96.6 (28/29) [82.2-99.9] N.D. (0/0) [N.D.] 100 (28/28) [87.7-100] N.D. (0/1) [0-97.5] 96.6 (28/29) [82.2-99.9]
FNAB-C + -Tgm 92.9 (26/28) [76.5-99.1] N.D. (0/0) [N.D.] 100 (26/26) [86.8-100] N.D. (0/2) [0-84.2] 92.9 (26/28) [76.5-99.1]
FNAB-C + -Tgp + -Tgm 100 (29/29) [88.1-100] N.D. (0/0) [N.D.] 100 (29/29) [88.1-100] N.D. (0/0) [N.D.] 100 (29/29) [88.1-100]
Only PTC CLN (n = 26)
FNAB-C 95.7 (22/23) [78.1-99.9] N.D. (0/0) [N.D.] 100 (22/22) [84.6-100] N.D. (0/1) [0-97.5] 95.7 (22/23) [78.1-99.9]
FNAB-Tgp 100 (23/23) [85.2-100] N.D. (0/0) [N.D.] 100 (23/23) [85.2-100] N.D. (0/0) [N.D.] 100 (23/23) [85.2-100]
FNAB-Tgm 90.5 (19/21) [69.6-98.8] N.D. (0/0) [N.D.] 100 (19/19) [82.4-100] N.D. (0/2) [0-84.2] 90.5 (19/21) [69.6-98.8]

Upper panel includes 26 CLN with metastatic PTC and ATC. Lower panel includes 23 CLN with only metastatic PTC. PPV, positive predictive value; NPV, negative predictive value; C, cytology; Tgp, thyroglobulin protein; Tgm, thyroglobulin mRNA. In bracket the number of cases. N.D., non-determined.

Baldini et al.

Baldini et al. BMC Clinical Pathology 2013 13:7   doi:10.1186/1472-6890-13-7

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