Table 1

Clinicopathological implication of Ki67-p53 combination status in surgically resected hormone receptor-positive breast cancers
Variables Cases
Ki67-p53 combination status
Total Low Ki67 LIand Negative p53 High Ki67 LI and/or Positive p53 P - value
(n=150) (n=88) (n=62)
Age
   ≦50 71 40 31
   >50 79 48 31 0.58
Tumor size
   <5.0 cm 128 78 50
   ≧5.0 cm 19 8 11 0.12
   Unknown 3 2 1
Lymph node metastasis
   (−) 84 52 32
   (+) 63 34 29 0.33
   Unknown 3 2 1
Stage
   I or II 129 78 51
   III 17 7 10 0.13
   Unknown 4 3 1
Nuclear grade
   1, 2 115 76 39
   3 35 12 23 0.0008
HER2 status
   Negative 142 88 54
   Positive 8 0 8 0.0006
Basal phenotype marker (CK5/6, CK14, EGFR)
   Negative 140 87 53
   Positive 10 1 9 0.0016
FOXA1
   Negative 20 14 6
   Positive 127 72 55 0.38
   NE 3 2 1
GATA3
   Negative 30 18 12
   Positive 120 70 50 0.99
P-cadherin
   Low 94 62 32
   High 56 26 30 0.0019
Chemotherapy
   No 98 59 39 0.59
   Yes 52 29 23

Abbreviation: LI labeling index, NE not evaluable.

Kobayashi et al.

Kobayashi et al. BMC Clinical Pathology 2013 13:5   doi:10.1186/1472-6890-13-5

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