Open Access Research article

VRK2 identifies a subgroup of primary high-grade astrocytomas with a better prognosis

Irene Rodríguez-Hernández123, Marta Vázquez-Cedeira12, Angel Santos-Briz34, Juan L García1, Isabel F Fernández13, Juan A Gómez-Moreta5, Javier Martin-Vallejo6, Rogelio González-Sarmiento123* and Pedro A Lazo12*

Author Affiliations

1 Instituto de Biología Molecular y Celular del Cáncer, CSIC-Universidad de Salamanca, Campus Miguel de Unamuno, 37007 Salamanca, Spain

2 Instituto de Investigación Biomédica de Salamanca-IBSAL, Hospital Universitario de Salamanca, Salamanca, Spain

3 Unidad de Medicina Molecular, Departamento de Medicina, Universidad de Salamanca, Salamanca, Spain

4 Departamento de Patología, Hospital Universitario de Salamanca, Salamanca, Spain

5 Departamento de Neurocirugía, Hospital Universitario de Salamanca, Salamanca, Spain

6 Departamento de Estadística, Universidad de Salamanca, Salamanca, Spain

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BMC Clinical Pathology 2013, 13:23  doi:10.1186/1472-6890-13-23

Published: 1 October 2013

Additional files

Additional file 1: Table S1:

Astrocytoma patient characteristics.

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Additional file 2: Table S2:

Individual characteristics of all astrocytoma cases studied. The information includes tumor localization, patient age and sex, survival and genetic information (p53, IDH1/2 status, EGFR, PTEN and MGMT methylation).

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Additional file 3: Table S3:

Sequence of primers used for detection of mutations in p53 and IDH1/2 genes.

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Additional file 4: Figure S1:

Expression level of VRK1, VRK2, p63, Ki-67 and p53 by immunohistochemistry to show cases considered to be either positive or negative.

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Additional file 5: Table S4:

Comparison of VRK1 and VRK2 expression with mutational status in astrocytomas.

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Additional file 6: Figure S2:

Expression of VRK1 and VRK2 in glioblastoma cell lines.

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