Table 2

Overall concordance analysis between manual and automated HER2 for four continuous HER2/CEP17 FISH parameters
Manual HER2 FISH Automated HER2 FISH Correlation analysis Linear regression analysis
Parameter Mean ± SD Mean ± SD Pearson correlation coefficient P value Slope Intercept R square
HER2 copy number 6.41 ± 4.6 5.87 ± 4.2 0.947 0.01 0.863 0.338 0.898
CEP17 copy number 2.02 ± 0.43 2.24 ± 0.59 0.705 0.01 0.962 0.299 0.497
HER2/CEP17 ratio 3.13 ± 2.19 2.56 ± 1.71 0.943 0.01 0.738 0.255 0.890
Proportion of carcinoma cells with HER2/CEP17 ratio >2.2 (%) 46.6 ± 41.6 41.1 ± 39.4 0.970 0.01 0.919 −1.732 0.942

Öhlschlegel et al.

Öhlschlegel et al. BMC Clinical Pathology 2013 13:13   doi:10.1186/1472-6890-13-13

Open Data