Table 2

Univariate and multivariate analyses of OS, DFS and PFS in relation to clinical parameters and Trop-2 protein expression
OS DFS PFS
Variables N=97 HR 95%CI p N=93 HR 95%CI p N=97 HR 95%CI p
Univariate analysis
Age
<65 vs ≥65 103 1.23 0.46-3.28 0.68 93 1.06 0.41-2.75 0.90 102 1.37 0.49-3.79 0.54
FIGO stage
III-IV vs I-II 97 17.05 5.47-53.17 <0.01 93 5.88 2.25-15.34 <0.01 96 16.73 5.28-53.03 <0.01
Tumor grade
G1 vs G2-G3 103 0.001 -* 0.68 99 0.155 0.02-1.18 0.07 102 0.001 -* 0.69
Lymph node involvement
positive vs negative 87 10.17 3.22-32.11 <0.01 85 6.05 2.09-17.51 <0.01 86 14.07 4.08-48.49 <0.01
Trop-2 IHC
score=3 vs score 0/1/2 103 2.60 0.94-7.19 0.06 99 3.36 1.26-8.92 0.01 102 2.80 0.99-7.87 0.05
Multivariate analysis
Trop-2 IHC 97 93 97
score=3 vs score 0/1/2 1.83 0.65-5.18 0.25 2.82 1.05-7.58 0.04 1.76 0.63-4.88 0.28
FIGO stage 97 93 97
III-IV vs I-II 15.94 5.08-50.04 <0.001 5.36 2.04-14.08 <0.001 16.73 5.31-52.73 <0.001

*Because of the small number of events (deaths and progressions) in the G1 EEC category, the confidence interval was not reliable.

Bignotti et al.

Bignotti et al. BMC Clinical Pathology 2012 12:22   doi:10.1186/1472-6890-12-22

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