Table 4

Excerpt of a list of the probabilities to detect a 5% bias with 95% certainty at the limits of the reference ranges limited to the comparison of tubes 11 to tubes 22.

11:22

11:22

Analyse

Ref. limits

Bias

95% Cl

SE

Bias Goal

p

Analyse

Ref. limits

Bias

95% Cl

SE

Bias Goal

p


Alb

35

0.3

0.0 to 0.5

0.12

1.8

<0.0001

HDL

0.9

0.0

0.0 to 0.0

0.00

0.0

<0.0001

Alb

58

1.6

-0.1 to 3.3

0.85

2.9

0.0683

Iron

10.6

0.1

0.0 to 0.2

0.05

0.5

<0.0001

AP

117

0.5

-0.3 to 1.2

0.39

5.9

<0.0001

Iron

28.3

0.4

0.1 to 0.8

0.17

1.4

<0.0001

ALTL

41

0.2

-0.1 to 0.6

0.19

2.1

<0.0001

K

3.5

0.0

0.0 to 0.1

0.01

0.2

<0.0001

Amy-P

53

0.0

-0.4 to 0.5

0.23

2.7

<0.0001

K

4.5

0.0

0.0 to 0.1

0.03

0.2

<0.0001

Amyl

100

1.0

0.3 to 1.7

0.35

5.0

<0.0001

LDH

288

10.1

0.9 to 19.3

4.56

14.4

0.1746

ASTL

37

0.2

-0.2 to 0.6

0.19

1.9

<0.0001

LDL

3.9

0.1

0.0 to 0.2

0.04

0.2

0.0019

Bili-D

2

0.0

0.0 to 0.1

0.03

0.1

0.0039

Lipe

60

0.5

0.0 to 1.1

0.28

3.0

<0.0001

Bili-T

20

0.0

-0.2 to 0.3

0.13

1.0

<0.0001

Mg

0.75

0.0

0.0 to 0.0

0.00

0.0

0.0138

Ca

2.02

0.0

0.0 to 0.0

0.01

0.1

<0.0001

Mg

1.25

0.0

0.0 to 0.0

0.01

0.1

<0.0001

Ca

2.6

0.0

0.0 to 0.0

0.01

0.1

<0.0001

Myo

28

0.2

-0.2 to 0.5

0.16

1.4

<0.0001

CHE

3000

-7.7

-61.1 to 45.7

26.47

150.0

<0.0001

Myo

72

-0.3

-0.9 to 0.3

0.31

3.6

<0.0001

CHE

11000

132.0

8.9 to 255.0

60.99

550.0

<0.0001

Na

135

0.1

-0.2 to 0.3

0.13

6.8

<0.0001

Chol

3.1

0.0

-0.1 to 0.0

0.03

0.2

<0.0001

Na

145

-0.5

-1.2 to 0.2

0.34

7.3

<0.0001

Chol

6.5

0.1

0.0 to 0.2

0.07

0.3

0.0011

Phos

0.87

0.0

0.0 to 0.0

0.01

0.0

<0.0001

CK

195

0.8

-0.9 to 2.5

0.82

9.8

<0.0001

Phos

1.45

0.0

0.0 to 0.0

0.01

0.1

<0.0001

CKMB

4.94

-0.1

-0.2 to 0.0

0.04

0.2

<0.0001

Pro-BNP

125

0.3

-0.9 to 1.6

0.63

6.3

<0.0001

CO2

22

-0.1

-0.4 to 0.1

0.11

1.1

<0.0001

PTH

1.59

0.0

-0.1 to 0.1

0.04

0.1

0.0435

CO2

29

-0.4

-0.7 to -0.0

0.17

1.5

<0.0001

PTH

9.33

-0.1

-0.3 to -0.0

0.05

0.5

<0.0001

Cort

82

0.9

-5.3 to 7.1

3.07

4.1

0.1509

RubG

10

0.0

-0.4 to 0.4

0.19

0.5

0.0111

Cort

958

0.3

-10.4 to 10.9

5.27

47.9

<0.0001

T3

1.3

0.0

0.0 to 0.0

0.01

0.1

<0.0001

Crea

59

0.1

-0.4 to 0.7

0.29

3.0

<0.0001

T3

3.1

0.0

-0.1 to 0.1

0.05

0.2

0.0054

Crea

104

0.0

-0.5 to 0.4

0.23

5.2

<0.0001

TN-T

0.01

0.0

0.0 to 0.0

0.00

0.0

<0.0001

CRP

10

0.1

-0.1 to 0.2

0.08

0.5

<0.0001

TNT-hs

0.014

0.0

0.0 to -0.0

0.00

0.0

<0.0001

Cl

97

0.1

-0.3 to 0.5

0.18

4.9

<0.0001

ToxoG

1

0.0

0.0 to 0.0

0.00

0.1

<0.0001

Cl

110

0.0

-0.4 to 0.4

0.20

5.5

<0.0001

TP

66

0.4

0.0 to 0.8

0.19

3.3

<0.0001

Ferri

30

-0.1

-0.4 to 0.2

0.15

1.5

<0.0001

TP

87

0.8

-0.4 to 2.0

0.59

4.4

<0.0001

Ferri

400

2.7

-0.9 to 6.2

1.77

20.0

<0.0001

Trigl

2.3

0.0

0.0 to 0.0

0.01

0.1

<0.0001

Fol

10.4

-0.1

-0.6 to 0.4

0.24

0.5

0.0484

Trfe

23

0.1

-0.1 to 0.3

0.09

1.2

<0.0001

Fol

78.9

1.6

-0.9 to 4.1

1.25

3.9

0.0343

Trfe

45

1.0

-0.2 to 2.3

0.62

2.3

0.0273

FT3

3.1

0.0

0.0 to 0.1

0.02

0.2

<0.0001

TSH

0.34

0.0

0.0 to 0.0

0.01

0.0

0.0873

FT3

6.8

-0.1

-0.2 to 0.1

0.07

0.3

0.0003

TSH

5.6

0.0

-0.1 to 0.1

0.05

0.3

<0.0001

FT4

12

0.0

-0.1 to 0.1

0.06

0.6

<0.0001

UA

420

0.9

-0.4 to 2.2

0.63

21.0

<0.0001

FT4

22

0.2

-0.1 to 0.4

0.11

1.1

<0.0001

Ureal

3

0.0

0.0 to 0.0

0.01

0.2

<0.0001

GGT

49

0.2

-0.1 to 0.6

0.18

2.5

<0.0001

Ureal

8

0.0

0.0 to 0.0

0.01

0.4

<0.0001

Gluc

3.9

0.0

-0.1 to 0.1

0.06

0.2

0.0029

VitB12

133

1.8

-2.5 to 6.1

2.15

6.7

0.0144

Gluc

5.8

0.0

0.0 to 0.1

0.04

0.3

<0.0001

VitB12

675

0.8

-7.7 to 9.3

4.20

33.8

<0.0001

HAV

20

0.0

-0.1 to 0.1

0.04

1.0

<0.0001

VitD

75

0.6

-1.0 to 2.3

0.80

3.8

0.0002

HCGbeta

2

0.0

0.0 to 0.1

0.02

0.1

0.0002


Those conditions not sensitive enough to detect a 5% bias were retested for a 10, 20, 30 or 40% bias (data not shown). The column heading Ref. limits means limits of reference ranges. At these concentrations of the analyte, the probability was tested to detect a 5% bias. Bias: The calculated deviation of the Deming regression line and its 95% confidence intervals (CI) and the standard error are given. Bias goal corresponds to a 5% deviation of the Deming regression line from identity at the tested analyte concentration. The full information on all comparisons is given in supplemental Table S2.

Minder et al. BMC Clinical Pathology 2011 11:6   doi:10.1186/1472-6890-11-6

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