Table 2

Mutations associated with RIF and INH resistance in the eight resistant isolates.

RIF susceptibility pattern

INH susceptibility pattern

KatG probes

inhA probes

Study

number

Indirect

Method

rpoβ gene

WT probes

rpoβ gene

Mutant probes

Indirect

Method

WT

Mutant

WT1

WT2

Mutant


08

R

D516V, H526Y,

H526D

R

WT

wt

WT

C15T

29

R

D516V

S

WT

WT

WT

47

R

D516V

S

WT

WT

WT

102

R

R

wt

S315T1

WT

WT

291

R

Δ8

S531L

R

wt

S315T1

WT

WT

246

S

R

wt

S315T2

WT

WT

248

R

Δ1

S

WT

WT

WT

437

R

S531L

S

WT

WT

WT


INH = isoniazid; RIF = rifampicin; R = drug resistant isolate; S = drug susceptible isolate; Indirect method = proportion method on Lowenstein-Jensen media.

Bazira et al. BMC Clinical Pathology 2010 10:5   doi:10.1186/1472-6890-10-5

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