|
Effects of Pasipay on PTZ-induced convulsion in mice |
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| Treatment (dose) |
Onset (sec) |
Duration (sec) |
Seizure protection (%) |
Mortality protection (%) |
|
|
||||
| Normal saline (10 ml/kg) |
51.83 ± 64 |
12 ± 1.80 |
0 |
0 |
| Diazepam (0.5 mg/kg) |
485.5 ± 74.97*** |
3.5 ± 2.21* |
80 |
90 |
| Diazepam (1 mg/kg) |
600 ± 0*** |
0 ± 0*** |
100 |
100 |
| Pasipay (0.05 mg/kg) |
56 ± 4.51 |
15.3 ± 4.48 |
0 |
0 |
| Pasipay (0.1 mg/kg) |
112.66 ± 16.2 |
7.1 ± 2.5 |
10 |
50 |
| Pasipay (0.2 mg/kg) |
137.6 ± 17.8*** |
7 ± 1.1 |
20 |
80 |
| Pasipay (0.4 mg/kg) |
600 ± 0*** |
0 ± 0*** |
100 |
100 |
|
Normal saline, diazepam and Pasipay were administered i.p. 30 min before the injection of PTZ (90 mg/kg, i.p.); Values are the mean ± S.E.M. for 10 mice. *p < 0.05;*** p < 0.001, compared to saline group, Tukey-Kramer test. | ||||
Nassiri-Asl et al. BMC Complementary and Alternative Medicine 2007 7:26 doi:10.1186/1472-6882-7-26 |
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