Table 1

Showing mean ± SE of AST and ALT activities and reduced glutathione content in blood and liver of different treatment groups of mice at different time intervals.

Time Intervals

Tissue

Series

24 h

48 h

72 h

7 d

15 d

30 d

ALT activity (μM/mg protein/min)

Liver

Dw

0.244 ± 0.073

0.293 ± 0.034

0.318 ± 0.030

0.339 ± 0.085

0.328 ± 0.067

0.321 ± 0.065

As

0.280 ± 0.053

0.299 ± 0.048

0.344 ± 0.051

0.640 ± 0.024^b

0.689 ± 0.065^b

0.643 ± 0.063^b

As+Ars Alb-30

0.328 ± 0.077

0.217 ± 0.044

0.319 ± 0.084

0.466 ± 0.039^b

0.473 ± 0.067^a

0.322 ± 0.080^a

As+Ars Alb-200

0.257 ± 0.093

0.264 ± 0.044

0.327 ± 0.068

0.518 ± 0.062

0.306 ± 0.056^b

0.277 ± 0.050^a

As+A-30

0.653 ± 0.113

0.318 ± 0.060

0.399 ± 0.042

0.599 ± 0.109^b

0.644 ± 0.100

0.650 ± 0.091

As+A-200

0.511 ± 0.079

0.345 ± 0.045

0.396 ± 0.064

0.610 ± 0.078

0.660 ± 0.074

0.767 ± 0.096

Blood

Dw

0.715 ± 0.032

0.740 ± 0.093

0.987 ± 0.081

0.766 ± 0.062

0.639 ± 0.034

0.736 ± 0.066

As

0.651 ± 0.097

0.910 ± 0.065

1.311 ± 0.109^a

1.004 ± 0.076^a

0.950 ± 0.079^b

1.003 ± 0.059^a

As+Ars Alb-30

0.741 ± 0.069

0.630 ± 0.019

0.852 ± 0.094^a

0.878 ± 0.088

0.307 ± 0.044^c

0.273 ± 0.044^c

As+Ars Alb-200

0.538 ± 0.066

0.521 ± 0.050

1.049 ± 0.093

0.875 ± 0.070

0.571 ± 0.082^a

0.409 ± 0.061^c

As+A-30

1.209 ± 0.133

0.938 ± 0.098

1.617 ± 0.097

0.939 ± 0.063^b

1.253 ± 0.106

0.902 ± 0.063

As+A-200

0.564 ± 0.034

1.002 ± 0.103

1.522 ± 0.097

0.928 ± 0.107

1.106 ± 0.194

1.212 ± 0.121

AST activity (μM/mg protein/min)

Liver

Dw

0.288 ± 0.038

0.214 ± 0.033

0.233 ± 0.042

0.259 ± 0.039

0.272 ± 0.016

0.257 ± 0.018

As

0.289 ± 0.024

0.282 ± 0.026

0.236 ± 0.018

0.433 ± 0.043^a

0.341 ± 0.024^a

0.319 ± 0.019^a

As+Ars Alb-30

0.241 ± 0.023

0.224 ± 0.037

0.215 ± 0.022

0.222 ± 0.018^b

0.308 ± 0.045

0.216 ± 0.044

As+Ars Alb-200

0.250 ± 0.043

0.278 ± 0.046

0.213 ± 0.037

0.241 ± 0.011^b

0.194 ± 0.031^b

0.088 ± 0.009^c

As+A-30

0.255 ± 0.037

0.301 ± 0.033

0.276 ± 0.045

0.327 ± 0.023^a

0.372 ± 0.047^a

0.239 ± 0.058

As+A-200

0.333 ± 0.062

0.285 ± 0.026

0.243 ± 0.034

0.363 ± 0.041

0.339 ± 0.040

0.298 ± 0.036

Blood

Dw

0.199 ± 0.023

0.221 ± 0.016

0.241 ± 0.014

0.239 ± 0.016

0.243 ± 0.016

0.243 ± 0.009

As

0.309 ± 0.018^b

0.282 ± 0.020^a

0.424 ± 0.021^c

0.294 ± 0.013^a

0.530 ± 0.053^c

0.383 ± 0.018^c

As+Ars Alb-30

0.247 ± 0.025

0.204 ± 0.015^a

0.204 ± 0.004^c

0.194 ± 0.026^b

0.304 ± 0.029^b

0.287 ± 0.026^a

As+Ars Alb-200

0.263 ± 0.015

0.210 ± 0.009^a

0.249 ± 0.020^c

0.200 ± 0.015^a

0.268 ± 0.027^b

0.229 ± 0.018^c

As+A-30

0.385 ± 0.026^a

0.311 ± 0.041

0.426 ± 0.037

0.387 ± 0.031

0.549 ± 0.047

0.498 ± 0.036^a

As+A-200

0.389 ± 0.021^a

0.319 ± 0.028

0.478 ± 0.041

0.293 ± 0.031

0.542 ± 0.061

0.460 ± 0.033

GSH Content (μM/mg of Liver)

Liver

Dw

1.383 ± 0.064

1.240 ± 0.051

1.162 ± 0.072

1.359 ± 0.072

1.376 ± 0.111

1.238 ± 0.110

As

1.447 ± 0.066

1.061 ± 0.035^a

0.978 ± 0.073

0.757 ± 0.033^c

0.782 ± 0.092^b

0.615 ± 0.098^b

As+Ars Alb-30

1.483 ± 0.086

1.377 ± 0.065^b

1.344 ± 0.066^b

1.207 ± 0.122^b

1.196 ± 0.109^a

1.055 ± 0.045^b

As+Ars Alb-200

1.580 ± 0.105

1.145 ± 0.084

1.230 ± 0.093

1.173 ± 0.108^b

1.265 ± 0.084^b

1.187 ± 0.077^b

As+A-30

1.360 ± 0.119

0.817 ± 0.082^a

0.818 ± 0.048

0.832 ± 0.115^b

0.697 ± 0.116

0.474 ± 0.045

As+A-200

1.436 ± 0.109

0.924 ± 0.117

0.937 ± 0.100

0.758 ± 0.074

0.718 ± 0.091

0.692 ± 0.035

GSH Content (nM/ml of Blood)

Blood

Dw

296.779 ± 6.948

274.076 ± 9.037

284.093 ± 6.839

275.882 ± 8.284

274.503 ± 7.090

241.913 ± 12.136

As

275.882 ± 11.433

245.502 ± 7.214^a

265.208 ± 11.621

237.456 ± 7.442^b

142.375 ± 16.466^c

110.200 ± 7.47^c

As+Ars Alb-30

303.881 ± 9.855

300.925 ± 14.232^b

286.556 ± 16.079

236.388 ± 15.958

284.011 ± 18.742^c

182.191 ± 14.149^c

As+Ars Alb-200

281.630 ± 11.363

226.324 ± 13.620

274.651 ± 14.291

299.037 ± 17.341^a

313.898 ± 12.932^c

286.967 ± 7.691^b

As+A-30

240.248 ± 17.659

236.635 ± 3.915

235.239 ± 10.893

102.569 ± 6.585^b

104.811 ± 6.347

87.281 ± 9.834

As+A-200

259.953 ± 8.857

274.856 ± 14.680

181.869 ± 12.780^c

153.213 ± 17.617^b

146.809 ± 13.915

106.740 ± 6.259

Superscript on the value of As series show level of significance in t-test between Dw and As and that on other series show the level of significance of t-test between As and that series. a = p < 0.05, b = p < 0.01, c = p < 0.001

Mallick et al. BMC Complementary and Alternative Medicine 2003 3:7   doi:10.1186/1472-6882-3-7