Table 1

Influence of atropine, mepyramine and propranolol on the hypotensive response of T. arjuna in dogs.

Drug

Dose (n = 6)

Response

After Antagonist

Before Antagonist

Atropine (1 mg)

Mepyramine (20 µg)

Propranolol (30 µg)

T. arjuna

5 mg/kg

Hypotension

NS

NS

NS

T. arjuna

6 mg/kg

Hypotension

No Blockade

No Blockade

Blockade

T. arjuna

8 mg/kg

Hypotension

NS

NS

NS

T. arjuna

10 mg/kg

Hypotension

NS

NS

NS

T. arjuna

15 mg/kg

Hypotension

NS

NS

NS

T. arjuna

20 mg/kg(n = 2)

Severe Hypotension

NS

NS

NS

NS – not studied; n – number of animals.

Nammi et al. BMC Complementary and Alternative Medicine 2003 3:5   doi:10.1186/1472-6882-3-5