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Open Access Research article

A legume product fermented by Saccharomyces cerevisiae modulates cutaneous atopic dermatitis-like inflammation in mice

Chiou-Yueh Yeh1, Chiau-Jing Jung1, Ching-Ning Huang2, Ying-Che Huang2, Huei-Ting Lien1, Won-Bo Wang3, Li-Fang Wang4* and Jean-San Chia123*

Author Affiliations

1 Graduate Institute of Immunology, College of Medicine, National Taiwan University, No. 1, Jen Ai Road 1st Section, Taipei City 10051, Taiwan

2 Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, No.1, Changde St., Taipei City 100, Taiwan

3 Graduate Institute of Microbiology, College of Medicine, National Taiwan University, No. 1, Jen Ai Road 1st Section, Taipei City 10051, Taiwan

4 Department of Dermatology, College of Medicine, National Taiwan University, No. 1, Jen Ai Road 1st Section, Taipei 10051, Taiwan

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BMC Complementary and Alternative Medicine 2014, 14:194  doi:10.1186/1472-6882-14-194

Published: 18 June 2014

Abstract

Background

Isoflavone-containing soy products modulate allergic inflammation in mice. In our previously study, IFN-γ and IL-10 production increased in mice fed with Saccharomyces cerevisiae legume fermented product (SCLFP), demonstrating that SCLFP had immunomodulatory activity. In this study, we tested the anti-inflammatory effects of SCLFP in a mouse model of cutaneous atopic dermatitis inflammation induced by epicutaneous sensitization.

Methods

Epicutaneous exposure to protein allergens plus Staphylococcal enterotoxin B induced a T helper (Th)-2–dominant immune response as well as cutaneous atopic dermatitis-like inflammation in BALB/c mice. The thickness of the skin epithelium, eosinophil migration, and T helper responses were determined in patched skin and draining lymph nodes of mice fed with and without SCLFP.

Results

Epicutaneous exposure to protein allergens plus Staphylococcal enterotoxin B induced a T helper (Th)-2–dominant immune response as well as cutaneous atopic dermatitis-like inflammation in BALB/c mice. SCLFP feeding attenuated this cutaneous Th2 response, as evidenced by decreased thickening of the epidermis, less eosinophil infiltration, and lower levels of IL-5, IL-13, and CXCL11 expression compared to controls. Oral administration of SCLFP also modulated Th1 responses in draining lymph nodes, with lower levels of IFN-γ, IL-4, and IL-17 expression.

Conclusion

Oral intake of SCLFP modulated the induced Th2 inflammatory responses in skin and might have potential applications for the prevention and treatment of atopic dermatitis.

Keywords:
Saccharomyces cerevisiae legume fermented product; Epicutaneous sensitization; Th2 response; Eosinophil; Atopic dermatitis