Table 1

Biochemical parameters and the renal levels of cytokines in experimental animals at the end of the eight-week treatment
Normal rats STZ-diabetic rats
Vehicle Vehicle PSLR 200 PSLR 300
Body weight (BW) (g/rat) 370.39 ± 13.58d 240.99 ± 16.24b 264.25 ± 15.11b,c 307.72 ± 14.72a,c
Kidney weight (KW) (g) 1.29 ± 0.23c 2.43 ± 0.17a 1.85 ± 0.24a 1.52 ± 0.16
KW/BW ratio × 1000 3.48 ± 0.19d 10.08 ± 0.17b 7.00 ± 0.12b,c 4.94 ± 0.11b,c
Plasma glucose (mg/dl) 92.68 ± 8.59d 425.73 ± 18.07b 336.25 ± 14.92b,c 306.92 ± 15.31b,c
HbAlc (%) 4.79 ± 1.03d 14.31 ± 1.26b 11.75 ± 1.18b 10.91 ± 1.21b
Urine volume (ml/day) 9.26 ± 2.43d 28.16 ± 9.13 b 18.21 ± 6.28b,c 15.84 ± 7.31b,c
Urine protein (mg/day) 6.95 ± 2.84d 34.83 ± 5.29b 16.41 ± 4.13a,c 12.27 ± 5.21d
Plasma Cr (μmol/l) 38.50 ± 6.34d 96.29 ± 8.73b 84.10 ± 8.31b 67.92 ± 7.32b,c
BUN (mmol/l) 7.21 ± 1.58c 16.29 ± 2.80a 13.16 ± 2.11a 11.45 ± 2.21a,c
Ccr (ml/min) 3.88 ± 0.89d 1.65 ± 0.54b 2.37 ± 0.68a,c 2.77 ± 0.34d
Plasma AST (U/l) 125.85 ± 10.47d 374.68 ± 17.34b 219.88 ± 18.26b,c 159.57 ± 17.53d
Plasma ALT (U/l) 57.67 ± 7.92d 218.67 ± 17.12b 145.14 ± 15.78b,c 103.42 ± 13.24a,d
Renal IL-6 (pg/mg protein) 54.06 ± 8.46d 159.34 ± 11.38b 126.34 ± 10.28b,c 105.89 ± 10.94b,c
Renal TNF-α (pg/mg protein) 69.19 ± 9.34d 172.91 ± 10.11b 137.12 ± 9.13b,c 109.45 ± 7.51b,c
Renal IL-10 (pg/mg protein) 64.77 ± 4.17d 28.43 ± 4.25b 36.49 ± 3.91b,c 44.64 ± 3.77b,c

STZ-diabetic rats were dosed by oral gavage once per day for eight weeks with 200 mg/kg/day PSLR (PSLR 200), 300 mg/kg/day PSLR (PSLR 300). Normal or STZ-diabetic rats receiving vehicle treatment were given the same volume of vehicle (distilled water) used to disperse PSLR. Values (mean ± SD) were obtained for each group of 8 animals. aP < 0.05 and bP < 0.01 compared to the values of vehicle-treated normal rats, respectively. cP < 0.05 and dP < 0.01 compared to the values of vehicle-treated STZ-diabetic rats, respectively.

Lu et al.

Lu et al. BMC Complementary and Alternative Medicine 2014 14:156   doi:10.1186/1472-6882-14-156

Open Data