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Open Access Research article

Prophylactic effect of herbal-marine compound (HESA-A) on influenza A virus infectivity

Parvaneh Mehrbod12, Aini Ideris12*, Abdul Rahman Omar12 and Mohd Hair-Bejo12

Author Affiliations

1 Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 Serdang Selangor, Malaysia

2 Institute of Bioscience, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia

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BMC Complementary and Alternative Medicine 2014, 14:131  doi:10.1186/1472-6882-14-131

Published: 7 April 2014

Abstract

Background

Influenza virus is still a severe respiratory disease affecting human and other species. As conventional drugs are not recommended for long time because of side effects and drug resistance occurrence, traditional medication has been focused as alternative remedy. HESA-A is a natural compound from herbal-marine origin. Previous studies have reported the therapeutic properties of HESA-A on psoriasis vulgaris and different types of cancers and we also showed its anti-inflammatory effects against influenza A infection.

Methods

This study was designed to investigate the potential properties of HESA-A as prophylaxis or treatment. To investigate the prophylaxis or treatment activities of HESA-A, Madin-Darby Canine Kidney (MDCK) cells were exposed to HESA-A and influenza A virus in different manners of exposure and different time intervals. The results were evaluated by MTT and HA assays.

Results

It was found that HESA-A is much more effective against influenza cytopathic effects when it is applied for prophylaxis and also in concurrent treatment (p ≤ 0.05) but not in post-infection treatment (p ≥ 0.05).

Conclusion

In conclusion, HESA-A is significantly effective against influenza replication in prophylaxis application affecting the virus penetration/adsorption to the cell without any toxic effect on the cell viability.

Keywords:
HESA-A; H1N1; Influenza virus; HA; MTT