Table 5

Fifty per cent inhibition concentrations (IC50s) of Euphorbia hirta and Rauvolfia vomitoria extracts on Onchocerca volvulus microfilariae
Extract/Drug Time of mff exposure (hrs)
2 4 6 12 24 48
IC50s of Euphorbia hirta (μg/ml)
Crude 500 125 75 50 40 <6.25
Hexane >800 700 700 700 150 17.5
Chloroform 400 150 140 50 20 <6.25
Ethyl acetate 100 37.5 21.9 12.5 <6.25 <6.25
Water 400 150 90 25 18.8 <6.25
IC50s of Rauvolfia vomitoria (μg/ml)
Crude >800 400 350 300 300 <6.25
Hexane >800 700 600 450 200 <6.25
Chloroform 650 600 450 400 400 <6.25
Ethyl acetate 650 625 625 625 450 37.5
Water >800 >800 800 400 200 <6.25
IC50s of the reference drugs (μg/ml)
DMSPN 100 40.5 18.8 14.1 6.25 <6.25
Mel B 600 500 400 87.5 <6.25 <6.25

Attah et al.

Attah et al. BMC Complementary and Alternative Medicine 2013 13:66   doi:10.1186/1472-6882-13-66

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