Effect of resveratrol on lung metastasis. Following necropsy, lungs were excised from mice with GFP-MDA-MB-231 or GFP-MDA-MB-435 mammary tumors that received vehicle or 0.5, 5, or 50 mg/kg BW Res diets and analyzed for metastases by fluorescent microscopy followed by quantitative image analysis. (A) and (B), Relative integrated density (±SEM) of fluorescent metastatic foci for vehicle or Res treated mice from the study performed with (A), MDA-MB-231 and (B), MDA-MB-435 cells (2-9 mice/group). Differences between means were determined using Student’s t-Test. Asterisk denotes statistical significance at p≤0.05.
Castillo-Pichardo et al. BMC Complementary and Alternative Medicine 2013 13:6 doi:10.1186/1472-6882-13-6