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Open Access Research article

Prevention of allergic airway hyperresponsiveness and remodeling in mice by Astragaliradix Antiasthmatic decoction

Su Xu1, Bao-Ping Tian1, Lan-Hong Zhang1, Wen Hua1, Li-Xia Xia1, Zhi-Hua Chen1, Wen Li1 and Hua-Hao Shen12*

Author Affiliations

1 Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Medicine, 88 Jiefang Rd., Hangzhou 310009, China

2 State Key Laboratory of Respiratory Diseases, Guangzhou 510120, China

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BMC Complementary and Alternative Medicine 2013, 13:369  doi:10.1186/1472-6882-13-369

Published: 25 December 2013

Abstract

Background

Astragali radix Antiasthmatic Decoction (AAD), a traditional Chinese medication, is found effective in treating allergic diseases and chronic cough. The purpose of this study is to determine whether this medication could suppress allergen-induced airway hyperresponsiveness (AHR) and remodeling in mice, and its possible mechanisms.

Methods

A mouse model of chronic asthma was used to investigate the effects of AAD on the airway lesions. Mice were sensitized and challenged with ovalbumin (OVA), and the extent of AHR and airway remodeling were characterized. Cells and cytokines in the bronchoalveolar lavage fluid (BALF) were examined.

Results

AAD treatment effectively decreased OVA-induced AHR, eosinophilic airway inflammation, and collagen deposition around the airway. It significantly reduced the levels of IL-13 and TGF-β1, but exerted inconsiderable effect on INF-γ and IL-10.

Conclusions

AAD greatly improves the symptoms of allergic airway remodeling probably through inhibition of Th2 cytokines and TGF-β1.

Keywords:
Astragalus Antiasthmatic Decoction; Airway hyperresponsiveness; Airway remodeling