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Open Access Research article

Guava pomace: a new source of anti-inflammatory and analgesic bioactives

Carina Denny1*, Priscilla S Melo2, Marcelo Franchin1, Adna P Massarioli2, Keityane B Bergamaschi2, Severino M de Alencar2 and Pedro L Rosalen1

Author Affiliations

1 Department of Physiological Sciences, Piracicaba Dental School, University of Campinas – UNICAMP, P.O. Box 52, 13414-018 Piracicaba, SP, Brazil

2 Department of Agri-food Industry, Food and Nutrition, "Luiz de Queiroz" College of Agriculture, University of São Paulo, Piracicaba, SP, Brazil

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BMC Complementary and Alternative Medicine 2013, 13:235  doi:10.1186/1472-6882-13-235

Published: 24 September 2013

Abstract

Background

Guava pomace is an example of the processing waste generated after the manufacturing process from the juice industry that could be a source of bioactives. Thus, the present investigation was carried out in order to evaluate the anti-inflammatory and antinociceptive potential and determinate the main phenolic compounds of a guava pomace extract (GPE).

Methods

The anti-inflammatory activity was evaluated by carrageenan, dextran, serotonin, histamine-induced paw edema and neutrophils migration in the peritoneal cavity models. Acetic acid-induced abdominal writhing and formalin test were performed to investigate the antinociceptive effects. In addition, the content of total phenolic and of individual phenolic compounds was determined by GC/MS.

Results

GPE showed anti-inflammatory activity by carrageenan, dextran, serotonin, histamine-induced paw edema and neutrophils migration in the peritoneal cavity models (p < 0.05). GPE also demonstrated antinociceptive activity by acetic acid-induced abdominal writhing and formalin test (p < 0.05). The total phenolic value was 3.40 ± 0.09 mg GAE/g and epicatechin, quercetin, myricetin, isovanilic and gallic acids were identified by GC/MS analysis.

Conclusions

The presence of bioactive phenolic compounds as well as important effects demonstrated in animal models suggest that guava pomace could be an interesting source of anti-inflammatory and analgesic substances.

Keywords:
Agro-industrial residue; Anti-inflammatory; Antinociceptive; Quercetin; Epicatechin; Guava pomace