Table 1

Effect of AC-PACs on the levels of phosphorylated protein kinases induced by C. albicans in oral epithelial cells

Phosphorylated protein kinase

Amounts of phosphorylated protein kinase (pg/ml)

No stimulation

C. albicans stimulation (MOI = 15)

No pre-treatment

AC-PAC pre-treatment


AKT (Ser 473)

614 ± 171

1184 ± 186*

782 ± 110*

AKT (Thr 308)

60 ± 17

111 ± 29*

113 ± 24

MEK1 (Ser 217/Ser 221)

2072 ± 383

6359 ± 255*

3596 ± 773

ERK1/2 (Thr 202/Tyr 204)

67 ± 2

97 ± 8*

41 ± 6


The data are the means ± SD of triplicate assays. *significantly higher compared to the unstimulated control (P < 0.05); significantly lower compared to the untreated (AC-PACs) control (P < 0.05).

Feldman et al. BMC Complementary and Alternative Medicine 2012 12:6   doi:10.1186/1472-6882-12-6

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