Table 1

Effects of Rg1 on blood pressure
WKY SHR SHR-Rg1(5) SHR-Rg1(10) SHR-Rg1(20)
SBP(mmHg) 133.7 ± 2.2 184.5 ± 3.4### 186.0 ± 2.4### 183.5 ± 3.3### 183.0 ± 4.2###
DBP(mmHg) 97.5 ± 2.0 139.0 ± 3.0### 138.0 ± 2.4### 139.1 ± 2.8### 133.8 ± 3.9###
HR (bpm) 360.6 ± 14.0 393.6 ± 12.5# 366.7 ± 13.7 412.6 ± 8.9 433.5 ± 9.3*
MAP(mmHg) 111.5 ± 6.3 170.1 ± 16.7### 181.6 ± 14.0### 175.4 ± 37.4### 193.7 ± 10.4###
EDP(mmHg) 6.1 ± 1.7 7.5 ± 3.0 3.1 ± 1.0 4.8 ± 3.9 5.5 ± 1.8
LVSP(mmHg) 120.9 ± 7.1 207.1 ± 17.9### 213.7 ± 21.1### 224.3 ± 35.4### 217.5 ± 16.8###
+dP/dtmax (mm HgS-1) 8661.1 ± 717.7 11735.7 ± 635.8## 13063.6 ± 470.8### 12651.9 ± 803.0## 12636.7 ± 514.7###
-dP/dtmax (mm HgS-1) −7514.6 ± 626.0 −11272.1 ± 872.8## −12410.0 ± 595.7### −11330.2 ± 722.8### −11464.1 ± 534.8###
HW/BW(mg/g) 2.9 ± 0.2 3.9 ± 0.05# 3.8 ± 0.08# 3.8 ± 0.07# 3.6 ± 0.06# **

All the values are expressed as mean ± S.E. Systolic pressure (SBP), diastolic pressure (DBP), heart rate (HR), mean arterial pressure (MAP), maximum rate of pressure development for relaxation (−dP/dtmax), maximum rate of pressure development for contraction (+dP/dtmax), left ventricular systolic pressure (LVSP) were demonstrated. Heart weight divided by body weight (HW/BW) is also calculated. MAP, EDP, LVSP, +dp/dtmax, -dp/dtmax were acquired using Millar catheter and recorded by PowerLab 8/30 instrument (ADInstruments, Australia). Heart rate, SBP and DBP were acquired by tail-cuff apparatus. Mean values of data from different treatment groups were compared using one-way ANOVA. After confirming the equal variances, unpaired Student’s t-test was used to compare difference between means of two groups using SigmaPlot software. #P < 0.05, ###P < 0.001 versus WKY; **P < 0.01, ***P < 0.001 versus SHR. n = 10 for each group.

Chen et al.

Chen et al. BMC Complementary and Alternative Medicine 2012 12:53   doi:10.1186/1472-6882-12-53

Open Data