Open Access Research article

Analysis of tanshinone IIA induced cellular apoptosis in leukemia cells by genome-wide expression profiling

Chang Liu1*, Jianqin Li1, Liangjie Wang4, Fuqun Wu2, Linfang Huang1, Yue Xu23, Jieyu Ye2, Bin Xiao23, Fanyi Meng2, Shilin Chen1 and Mo Yang24*

Author Affiliations

1 Institute of Medicinal Plant Development, Chinese Academy of Medical Science, 151 MaLianWa North Road, Beijing, 100193, P.R.China

2 Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China

3 Institute of Hematology, Medical College, Jinan University, Guangzhou 510632, P.R.China

4 LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, P.R. China

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BMC Complementary and Alternative Medicine 2012, 12:5  doi:10.1186/1472-6882-12-5

Published: 16 January 2012

Additional files

Additional file 1:

Table S1. List of primers for RT-qPCR. Table S2. List of significantly regulated genes after Tan IIA treatment in U-973 cells. Table S3. List of differentially expressed genes (> 1.5-fold changes) identified from Affymetrix GeneChip experiments that are involved in apoptosis, NF-κB signaling cascade and cell proliferation pathways. Table S4. List of correlations between expression profiles of each gene across the five cell lines and the cell lines' Tan IIA sensitivities to Tan IIA's treatment.

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