Table 3

Effect of test materials and propanolol (reference control) on heart rate of rats

Group

Dose

(mg/kg bw.)

Heart rate (beat/min)

Before induction of hypertension

After induction of hypertension

After treatment of hypertension

Normal

-

412 ± 4.3

415 ± 4.1

409 ± 4.5

Untreated control

-

399 ± 4.1

535 ± 5.4

570 ± 5.8

Propanolol-treated

10

410 ± 4.4

520 ± 5.5

405 ± 4.4

CUR

1000

411 ± 4.5

530 ± 5.5

530 ± 5.5

3000

401 ± 4.2

528 ± 5.3

518 ± 5.6

5000

390 ± 3.9

523 ± 5.4

471 ± 4.3

ZO

1000

420 ± 4.2

526 ± 4.9

499 ± 5.1

3000

418 ± 4.9

531 ± 5.7

474 ± 5.2

5000

415 ± 4.6

530 ± 5.5

416 ± 4.1*

AL

1000

403 ± 4.1

544 ± 5.4

431 ± 4.4*

3000

407 ± 4.3

540 ± 5.6

416 ± 4.3*

5000

398 ± 3.6

528 ± 5.3

410 ± 4.5*

PC

100

409 ± 4.0

537 ± 5.2

540 ± 5.6

500

410 ± 4.2

519 ± 5.3

427 ± 4.1*

1000

420 ± 4.5

509 ± 5.3

419 ± 4.6*

PPF

1000

412 ± 4.5

519 ± 5.2

559 ± 5.8

2000

398 ± 4.7

534 ± 5.6

544 ± 5.7

4000

405 ± 4.4

526 ± 5.5

536 ± 5.4

Data are presented as mean ± SEM values

*Statistically significant difference with baseline by paired t-test:

sBP and dBP of ZO-treated group at high dose level (p < 0.001)

sBP and dBP of AL-treated group at all dose levels (p < 0.001)

sBP and dBP of PC-treated group at medium and high dose levels (p < 0.001)

Plengsuriyakarn et al. BMC Complementary and Alternative Medicine 2012 12:23   doi:10.1186/1472-6882-12-23