Table 8

Effect of Nuna kadugu on biochemical parameters of experimental Sprague Dawley rats in repeated oral toxicity study
Treatment Sex Biochemical parameters
Glucose (mg/dl) Cholesterol (mg/dl) Triglycerides (mg/dl) T. Protein (gm%) Albumin (gm%) SGOT (IU/l) SGPT (IU/l)
Control (0.5% CMC) M(n=5) 128.90 ±12.51 88.01 ±5.69 45.18 ±8.56 4.63 ±0.28 2.27 ±0.13 30.40 ±4.04 33.92 ±3.38
F (n=5) 134.24 ±5.13 86.64 ±7.32 50.50 ±9.00 4.70 ±0.34 2.38 ±0.23 29.40 ±4.12 43.16 ±7.41
MF(n=10) 131.57±6.44 87.32±4.38 47.84±5.92 4.67±0.21 2.33±0.13 29.90±2.73 38.54±4.14
NK (300 mg/kg p.o/day) M(n=5) 131.16 ±9.57 87.98 ±10.81 51.20 ±11.66 4.90 ±0.13 2.43 ±0.15 29.92 ±5.31 43.83 ±6.02
F (n=5) 130.31 ±11.64 87.74 ±13.2 44.79 ±3.18 5.01 ±0.15 2.34 ±0.23 29.90 ±3.93 34.19 ±4.42
MF(n=10) 130.74±7.11 87.86±8.05 47.99±5.80 4.96±0.09 2.39±0.13 29.91±3.11 39.01±3.87
(600 mg/kg p.o/day) M(n=5) 128.35 ±12.39 89.26 ±3.32 50.57 ±1.53 4.82 ±0.27 2.22 ±0.29 29.10 ±3.69 40.99 ±4.52
F (n=5) 132.61 ±15.43 85.92 ±10.74 44.74 ±3.50 4.78 ±0.49 2.20 ±0.23 31.22 ±4.86 38.66 ±3.67
MF(n=10) 130.48±9.35 87.59±5.33 47.66±2.05 4.80±0.26 2.21±0.18 30.16±2.90 39.83±2.77
(900mg/kg p.o/day) M(n=5) 130.18 ±2.79 85.73 ±14.31 47.91 ±6.91 4.95 ±0.50 2.33 ±0.30 30.20 ±4.21 38.56 ±6.79
F (n=5) 130.58 ±13.84 88.77 ±14.81 47.05 ±5.99 4.66 ±0.28 2.24 ±0.13 31.08 ±6.96 41.00 ±8.08
MF(n=10) 130.38±6.66 87.25±9.72 47.48±4.31 4.80±0.28 2.28±0.15 30.64±3.84 39.78±4.99
Satellite group
Control (0.5% CMC) M(n=5) 134.32 ±8.85 89.59 ±10.96 47.55 ±3.73 4.92 ±0.32 2.34 ±0.25 31.14 ±1.17 39.68 ±4.37
F (n=5) 127.92 ±12.83 85.61 ±10.53 48.65 ±2.67 5.05 ±0.45 2.12 ±0.22 29.54 ±4.74 39.01 ±2.98
MF(n=10) 131.12±7.42 87.60±7.19 48.10±2.17 4.99±0.26 2.23±0.16 30.34±2.32 39.35±2.50
NK (900 mg/kg p.o/day) M(n=5) 131.55 ±4.12 87.57 ±5.61 46.79 ±5.22 4.80 ±0.31 2.20 ±0.13 24.96 ±4.73 39.88 ±4.38
F (n=5) 132.35 ±14.32 86.61 ±13.93 49.42 ±4.24 4.71 ±0.33 2.42 ±0.19 35.36 ±3.85 38.66 ±7.83
MF(n=10) 131.95±7.02 87.09±7.08 48.11±3.20 4.75±0.21 2.31±0.12 30.16±3.36 39.27±4.24
Treatment Sex Biochemical parameters
LDH (IU/L) ALP (IU/L) γ-GT (IU/L) Bilirubin (mg/dl) Creatinine (mg%) BUN (mg/dl)
Control (0.5% CMC) M(n=5) 178.20±9.72 329.00±46.89 2.39±0.23 0.83±0.03 0.43±0.05 19.07±0.63
F (n=5) 180.60±12.33 286.80±51.41 2.11±0.14 0.90±0.03 0.31±0.03 20.18±1.43
MF(n=10) 179.40±7.41 307.90±33.55 2.25±0.13 0.87±0.02 0.37±0.03 19.63±0.76
NK (300 mg/kg .o/day) M(n=5) 179.60±16.64 307.22±18.45 2.12±0.19 0.54±0.27 0.28±0.02 19.06±3.10
F (n=5) 178.20±12.08 310.06±14.29 2.10±0.20 1.00±0.08 0.35±0.03 18.08±1.28
MF(n=10) 178.90±9.69 308.64±11.01 2.11±0.13 0.77±0.15 0.31±0.02 18.57±1.59
(600 mg/kg p.o/day) M(n=5) 181.40±7.28 306.74±16.29 2.03±0.23 0.84±0.05 0.34±0.04 18.56±2.11
F (n=5) 179.80±11.51 311.32±32.42 1.96±0.20 0.84±0.06 0.34±0.04 20.26±1.33
MF(n=10) 180.60±6.42 309.03±25.89 1.99±0.14 0.84±0.04 0.34±0.03 19.41±1.21
(900mg/kg p.o/day) M(n=5) 178.20±14.03 310.82±35.07 2.04±0.21 0.99±0.04 0.37±0.03 19.62±1.65
F (n=5) 183.60±8.59 306.64±31.52 2.13±0.22 0.97±0.02 0.30±0.03 18.55±2.00
MF(n=10) 180.90±7.81 308.73±35.56 2.09±0.14 0.98±0.02 0.33±0.02 19.09±1.24
Satellite group
Control (0.5% CMC) M(n=5) 180.60±10.13 288.66±20.91 2.01±0.25 0.92±0.06 0.32±0.03 19.88±0.86
F (n=5) 181.60±16.71 330.98±50.39 2.06±0.28 0.93±0.05 0.34±0.03 20.78±1.10
MF(n=10) 181.10±9.21 309.82±26.66 2.04±0.18 0.93±0.04 0.33±0.02 20.33±0.68
NK (900 mg/kg p.o/day) M(n=5) 180.20±13.43 310.80±33.66 2.28±0.29 0.96±0.13 0.38±0.04 21.21±2.33
F (n=5) 181.20±14.59 308.42±36.41 1.85±0.23 0.930.04± 0.31±0.03 20.48±1.60
MF(n=10) 180.70±9.35 309.61±23.38 2.06±0.19 0.94±0.06 0.35±0.03 20.85±1.34

Values expressed as mean ± SEM; Significance with Tukey’s test following one way ANOVA is evaluated as *p < 0.05 and **p < 0.01 vs control group. SGOT – Serum Glutamate oxaloacetate transaminase; SGPT – Serum Glutamate pyruvate transaminase.

Values expressed as mean ± SEM; n=10 (5/sex); Significance with Tukey’s test following one way ANOVA is evaluated as *p < 0.05 and **p < 0.01 vs control group. LDH – Lactate dehydrogenase; ALP- Alkaline Phosphatase; GGT- Gamma Glutamyl Transferase; BUN – Blood Urea Nitrogen.

Ramaswamy et al.

Ramaswamy et al. BMC Complementary and Alternative Medicine 2012 12:190   doi:10.1186/1472-6882-12-190

Open Data