Table 1

Summary of the top 20 cancer and apoptosis-related gene expression changes in HSC-4 cells following ACA treatment for 1 h and 2 h. Genes were selected based on triplicates withp-values ≤ 0.05; and mean fold changes ≥ 1.50
Gene description GenBank ID p-value Fold change (0 h vs. 1h) Fold change (0 h vs. 2 h) NF-kB relation
Tumour protien p53 AK 125880 0.0090 2.01 1.91 Activator
F-box protien 21 BC034045 0.0009 1.95 1.73 Ubq.b
BCL2-associated X (Bax) AK291076 0.0106 1.83 1.54 Gene Targeta
Cyclin G2 BC032518 0.0216 1.74 1.65 Indirect Act.c
Tumour necrosis factor alpha (TNF-α) BC064689 0.0411 1.62 1.63 Gene Target
SMAD 6 AF035528 0.0120 1.58 1.58 Ubq.
Endonuclease G AK023235 0.0459 1.55 1.52 Gene Target
Poly (ADP-ribose) polymerase (PARP) BC031073 0.0432 1.54 1.56 Activator
Caspase 6 (CASP-6) U20536 0.0153 1.54 1.69 Indirect Act.
Cyclin-dependent kinase 2 (CDK-2) U35146 0.0383 1.53 1.51 Indirect Act.
v-fos FBJ murine osteosarcoman viral oncogene BX647104 0.0067 −8.53 −8.32 Activator
Jun oncogene BC068522 0.0016 −3.32 −3.11 Activator
Fibroblast growth factor 2 (FBF-2) J04513 0.0361 −1.84 −1.65 Gene Target
Lymphotoxin beta (LTB) L11015 0.0429 −1.74 −1.58 Gene Target
Nuclear factor of kappa inhibitor delta (lkB-δ) AF385434 0.0239 −1.65 −1.60 Inhibitor
Mitogen-activated protien 3-kinase (MAP3K) BC035576 0.0313 −1.59 −1.59 Activator
Tumour necrosis factor receptor (TNF-R) AF018253 0.0062 −1.56 −1.57 Gene Target
Tumour protien 73 (p73) AY040827 0.0394 −1.56 −1.59 Indirect Act.
TNFR-associated death domain (TRADD) BC004491 0.0421 −1.55 −1.55 Activator
TNF receptor-associated factor 1 (TRAF-1) AK090468 0.039 −1.52 −1.55 Gene Target

a Gene Target: contains κB site in promoter region.

b Ubq: involved in ubiquitination process of IκBs.

c Indirect Act: gene is activated by another κB-regulated gene.

In et al.

In et al. BMC Complementary and Alternative Medicine 2012 12:179   doi:10.1186/1472-6882-12-179

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