Curcumin (Cur) administration ameliorates hepatic inflammation and fibrosis induced by CCl4administration. (A) Haematoxylin and eosin (H&E) staining of the livers (original magnification, ×200). (B) Evaluation of liver fibrosis by Sirius red staining of liver sections (original magnification, ×200). (C) Semiquantitative evaluation of liver necro-inflammatory activity according to the METAVIR scoring system. *P < 0.05 for Cur/CCl4 vs. PBS/CCl4 (n = 8/group). (D) Quantitative image analysis of hepatic Sirius red staining using a computerized image analysis system; **P < 0.001 for Cur/CCl4 vs. PBS/CCl4 (n = 6-8/group).
Yao et al. BMC Complementary and Alternative Medicine 2012 12:156 doi:10.1186/1472-6882-12-156