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Open Access Research article

Laxative effects of partially defatted flaxseed meal on normal and experimental constipated mice

Jiqu Xu12, Xiaoqi Zhou3, Chang Chen4, Qianchun Deng12, Qingde Huang12, Jin'e Yang12, Nianhong Yang3 and Fenghong Huang12*

Author Affiliations

1 Department of Product Processing and Nutriology, Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, 2 Xudong Second Road, Wuhan 430062, People's Republic of China

2 Hubei Key Laboratory of Lipid Chemistry and Nutrition, Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, 2 Xudong Second Road, Wuhan 430062, People's Republic of China

3 Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, People's Republic of China

4 Department of Gastroenterology, The No.1 Hospital of Yichang, 2 Jiefang Road, yichang 443000, People's Republic of China

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BMC Complementary and Alternative Medicine 2012, 12:14  doi:10.1186/1472-6882-12-14

Published: 9 March 2012

Abstract

Background

Constipation is a very common health problem in the world. Intake of sufficient amount of dietary fibers is a cornerstone in the prevention and treatment of constipation. As a traditional medicine, flaxseed has been used to treat constipation for centuries, but the controlled trials are rare. The purpose of the present study was to assess that whether partially defatted flaxseed meal (PDFM) has the potential role to facilitate fecal output in normal and experimental constipated mice.

Methods

After supplemented with 2.5%, 5% and 10% (w/w) PDFM (L-, M- and H -PDFM) for 14 days, the constipation models of mice were induced by atropine-diphenoxylate. The small intestinal transit rates, start time of defecation, amount of defecation and wet weight of feces were researched in normal and constipation model mice.

Results

M- and H-PDFM significantly increase small intestinal transit rates in constipation model mice. All dose of PDFM markedly shortened the start time of defecation and M- and H-PDFM significantly increase stool frequency and weight in both normal and constipation model mice.

Conclusions

PDFM may be a useful laxative to facilitate fecal output in normal and constipation conditions.

Keywords:
Flaxseed; Constipation; Diphenoxylate; Dietary fibers; Laxative