Table 2

Determinants of HRT discontinuation: results of propensity analysis



Multivariate Logistic Regression Results*



Variable
 HRT Continuers (N = 1342)
 HRT Discontinuers (N = 1015)
 Parameter Estimate (β)
 Std. Error of β
 Adjusted Odds Ratio
 95% CI for Odds Ratio
 P-value
Age






     Age in years (mean)
 75.5
 75.5
 0.0081
 0.0075
 1.041
 0.993–1.023
 .2847
Race






     White (%) †
 96.7
 95.6
 --
 --
 1.000
 --
 --
     Black (%)
 2.7
 3.5
 0.3536
 0.2527
 1.424
 0.868–2.337
 .1616
     Other race (%)
 0.6
 1.0
 0.2903
 0.4992
 1.337
 0.503–3.556
 .5609
Income






     Annual income in thousands (mean)
 $13.805
 $13.999
 0.0537
 0.0245
 1.055
 1.006–1.117
 .0283
Marital status






     Widowed, divorced, or never married (%) †
 80.6
 80.5
 --
 --
 1.000
 --
 --
     Currently married (%)
 19.4
 19.5
 -0.1327
 0.1384
 0.876
 0.668–1.149
 .3378
Education






     12 or more years of education (%)
 60.5
 63.5
 0.0937
 0.0899
 1.098
 0.921–1.310
 .2971
Residence type






     Nursing or personal care facility (%)
 1.6
 1.0
 -0.4390
 0.4067
 0.645
 0.291–1.431
 .2804
Urban/rural residence






     Semi-rural or rural residence (%)
 33.6
 35.5
 0.1526
 0.0913
 1.165
 0.974–1.393
 .0948
Alcohol use






     Current alcohol user (%)
 26.5
 24.4
 -0.1335
 0.1008
 0.875
 0.995–1.022
 .1854
Smoking history






     Past or present smoker (%)
 34.7
 33.0
 -0.0573
 0.0924
 0.944
 0.788–1.132
 .5352
Type of HRT used at baseline






     Unopposed estrogen (%) †
 89.5
 74.2
 --
 --
 1.000
 --
 --
     Combination estrogen/progestin (%)
 10.5
 25.8
 1.1100
 .1171
 3.034
 2.412–3.817
 .0001
Baseline non-HRT prescription drug use






     Any cardiovascular drug use (%)
 78.8
 79.9
 0.2265
 0.1141
 1.254
 1.003–1.568
 .0471
     Any osteoporosis treatment (%)
 12.2
 15.4
 0.3100
 0.1270
 1.363
 1.063–1.749
 .0146
     Total number of non-HRT drug classes (mean)
 6.3
 5.9
 -0.0507
 0.0165
 0.951
 0.920–0.982
 .0021
Baseline HRQOL






     Days that physical health was not good (mean)
 6.3
 6.3
 0.0086
 0.0069
 1.009
 0.995–1.022
 .2174
     Days that mental health was not good (mean)
 3.3
 3.0
 -0.0042
 0.0067
 0.996
 0.983–1.009
 .5323
     Healthy days (mean) ‡
 21.9
 22.3
 --
 --
 --
 --
 --
     Days that health interfered (mean)
 4.2
 3.8
 -0.0113
 0.0077
 0.989
 0.974–1.004
 .1432
     Days that pain made it hard (mean)
 6.3
 6.4
 0.0060
 0.0064
 1.006
 0.993–1.019
 .3514

* All parameter estimates are adjusted for two-way interaction terms involving age, income, marital status, alcohol use, smoking history, prescription drug use, and baseline HRQOL.

† Reference group

‡ Because the healthy days variable is a composite of the physical and mental days measures, it was omitted from the logistic regression.

Heller et al. BMC Women's Health 2005 5:7   doi:10.1186/1472-6874-5-7