Table 3

BPI scores at baseline, end of IR phase, and end of SR phase (ITT population)

Variable
Baseline* Mean (SD)
End of IR phaseLS mean (SE)
End of SR phaseLS mean (SE)

Worst pain



     Hydromorphone
6.3 (2.7)
5.0 (0.3)
3.5 (0.3)
     Morphine
6.2 (2.5)
4.8 (0.3)
4.3 (0.3)

Least pain



     Hydromorphone
2.7 (2.5)
1.8 (0.2)
1.8 (0.2)
     Morphine
2.9 (2.7)
2.2 (0.2)
1.8 (0.2)

Average pain



     Hydromorphone
5.0 (2.1)
3.6 (0.2)
3.4 (0.3)
     Morphine
5.1 (2.1)
3.6 (0.2)
3.2 (0.3)

Pain now AM



     Hydromorphone
4.0 (2.7)
3.3 (0.3)
2.4 (0.3)
     Morphine
4.1 (2.4)
3.4 (0.3)
2.8 (0.3)

Pain now PM



     Hydromorphone
4.8 (3.0)
3.6 (0.3)
2.6 (0.3)§
     Morphine
4.2 (2.5)
3.7 (0.3)
3.4 (0.3)

Abbreviations: BPI, Brief Pain Inventory; CR, controlled-release; IR, immediate-release; LS, least-squares; SD, standard deviation; SE, standard error; SR, sustained-release

*Hydromorphone, n = 99; morphine, n = 101

†IR hydromorphone, n = 99; IR morphine, n = 101

‡OROS® hydromorphone, n = 77; CR morphine, n = 86

§p = 0.0372 versus CR morphine

Hanna et al. BMC Palliative Care 2008 7:17   doi:10.1186/1472-684X-7-17