Table 3

BPI scores at baseline, end of IR phase, and end of SR phase (ITT population)

Variable

Baseline* Mean (SD)

End of IR phase^† LS mean (SE)

End of SR phase^‡ LS mean (SE)

Worst pain

Hydromorphone

6.3 (2.7)

5.0 (0.3)

3.5 (0.3)

Morphine

6.2 (2.5)

4.8 (0.3)

4.3 (0.3)

Least pain

Hydromorphone

2.7 (2.5)

1.8 (0.2)

1.8 (0.2)

Morphine

2.9 (2.7)

2.2 (0.2)

1.8 (0.2)

Average pain

Hydromorphone

5.0 (2.1)

3.6 (0.2)

3.4 (0.3)

Morphine

5.1 (2.1)

3.6 (0.2)

3.2 (0.3)

Pain now AM

Hydromorphone

4.0 (2.7)

3.3 (0.3)

2.4 (0.3)

Morphine

4.1 (2.4)

3.4 (0.3)

2.8 (0.3)

Pain now PM

Hydromorphone

4.8 (3.0)

3.6 (0.3)

2.6 (0.3)^§

Morphine

4.2 (2.5)

3.7 (0.3)

3.4 (0.3)

Abbreviations: BPI, Brief Pain Inventory; CR, controlled-release; IR, immediate-release; LS, least-squares; SD, standard deviation; SE, standard error; SR, sustained-release

*Hydromorphone, n = 99; morphine, n = 101

†IR hydromorphone, n = 99; IR morphine, n = 101

‡OROS^® hydromorphone, n = 77; CR morphine, n = 86

§p = 0.0372 versus CR morphine

Hanna et al. BMC Palliative Care 2008 7:17   doi:10.1186/1472-684X-7-17