Table 1 |
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Characteristics of 7,879 patients with metastatic non-small cell lung cancer by receipt of chemotherapy |
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Variables |
No chemotherapy (n = 4,345) |
Standard chemotherapy (n = 3,235) |
Aggressive -approach chemotherapy (n = 299) |
P-value |
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3 groups |
No chemo-therapy vs. Chemo- therapy* |
Standard chemotherapy vs. Aggressive -approach chemotherapy |
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Age at diagnosis, years |
Median [IQR] |
73.0 [69.0-78.0] |
71.0 [68.0-74.0] |
70.0 [67.0-74.0] |
< 0.001 |
< 0.001 |
0.36 |
|
Gender, n (%) |
Female |
1,938 (44.6) |
1,291 (39.9) |
108 (36.1) |
< 0.001 |
< 0.001 |
0.20 |
|
Male |
2,407 (55.4) |
1,944 (60.1) |
191 (63.9) |
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Charlson comorbidity index, n (%) |
0 |
3,123 (71.9) |
2,401 (74.2) |
226 (75.6) |
< 0.001 |
< 0.001 |
0.06 |
|
1 |
773 (17.8) |
576 (17.8) |
60 (20.1) |
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2 ≤ |
449 (10.3) |
258 (8.0) |
13 (4.4) |
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Race/Ethnicity, n (%) |
non-Hispanic white |
3,551 (81.7) |
2,711 (83.8) |
254 (85.0) |
0.01 |
0.01 |
0.22 |
|
non-Hispanic black |
425 (9.8) |
248 (7.7) |
21 (7.0) |
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Hispanic or other |
369 (8.5) |
276 (8.5) |
24 (8.0) |
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Region of tumor registries, n (%) |
Northeast |
672 (15.5) |
555 (17.2) |
51 (17.1) |
< 0.01 |
< 0.01 |
0.06 |
|
South |
228 (5.3) |
194 (6.0) |
28 (9.4) |
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Midwest |
1,426 (32.8) |
1,101 (34.0) |
86 (28.8) |
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West |
2019 (46.5) |
1385 (42.8) |
134 (44.8) |
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Urban residence, n (%) |
Yes |
3,928 (90.4) |
2,973 (91.9) |
284 (95.0) |
< 0.01 |
< 0.01 |
0.06 |
|
No |
417 (9.6) |
262 (8.1) |
15 (5.0) |
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Socioeconomic status, n (%) |
Highest quintile |
763 (17.6) |
682 (21.1) |
71 (23.8) |
< 0.001 |
< 0.001 |
0.85 |
|
Fourth quintile |
793 (18.3) |
673 (20.8) |
63 (21.1) |
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Third quintile |
866 (19.9) |
688 (21.3) |
59 (19.7) |
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Second quintile |
849 (19.5) |
635 (19.6) |
56 (18.7) |
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Lowest quintile |
1,074 (24.7) |
557 (17.2) |
50 (16.7) |
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Median income |
Median [IQR] |
38,154 [29-152] |
41,205 [32-757] |
43,564 [32-179] |
< 0.001 |
< 0.001 |
0.28 |
|
Teaching hospital, n (%) |
Yes |
2,110 (48.6) |
1,868 (57.7) |
163 (54.5) |
< 0.001 |
< 0.001 |
0.28 |
|
No |
2,235 (51.4) |
1,367 (42.3) |
136 (45.5) |
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Year of death, n (%) |
1991 |
365 (8.4) |
206 (6.4) |
18 (6.0) |
< 0.001 |
< 0.001 |
0.02 |
|
1992 |
576 (13.3) |
299 (9.2) |
22 (7.4) |
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1993 |
567 (13.1) |
340 (10.5) |
15 (5.0) |
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1994 |
581 (13.4) |
339 (10.5) |
33 (11.0) |
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1995 |
518 (11.9) |
372 (11.5) |
33 (11.0) |
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1996 |
490 (11.3) |
424 (13.1) |
32 (10.7) |
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1997 |
442 (10.2) |
413 (12.8) |
46 (15.4) |
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1998 |
421 (9.7) |
421 (13.0) |
52 (17.4) |
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1999 |
385 (8.9) |
421 (13.0) |
48 (16.1) |
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Death in the hospital, n (%) |
Yes |
774 (17.8) |
812 (25.1) |
152 (50.8) |
< 0.001 |
< 0.001 |
< 0.001 |
|
No |
3,571 (82.2) |
2,423 (74.9) |
147 (49.2) |
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ICU admission within 1 month of death, n (%) |
Yes |
187 (4.3) |
213 (6.6) |
37 (12.4) |
< 0.001 |
< 0.001 |
< 0.001 |
|
No |
4,158 (95.7) |
3,022 (93.4) |
262 (87.6) |
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More than 1 ER visit within 1 month of death, n (%) |
Yes |
870 (20.0) |
857 (26.5) |
104 (34.8) |
< 0.001 |
< 0.001 |
< 0.01 |
|
No |
3,475 (80.0) |
2,378 (73.5) |
195 (65.2) |
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Hospice admission, n (%) |
None |
2,208 (50.8) |
1,668 (51.6) |
241 (80.6) |
< 0.001 |
< 0.001 |
< 0.001 |
|
Three or fewer days |
156 (3.6) |
198 (6.1) |
25 (8.4) |
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Four or more days |
1,981 (45.6) |
1,369 (42.3) |
33 (11.0) |
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Abbreviation: vs., versus; IQR, interquartile range; ICU, intensive care unit; ER, emergency room. *Chemotherapy includes standard chemotherapy or aggressive-approach chemotherapy |
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Saito et al. BMC Palliative Care 2011 10:14 doi:10.1186/1472-684X-10-14 |
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