|
Statin medication and periodontal inflammatory injury. |
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| Non-users n = 76 |
Statin users n = 21 |
Difference (% of control) |
95% CI (difference of means) |
P-value* |
|
|
|
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| A. Inflammatory burden† |
|||||
|
|
|||||
| PPD‡ ≥ 4 mm |
79.1(3.7) |
50.1 (7.0) |
29.0 (-37%) |
12.9 – 45.0 |
0.00043 |
| 4 mm ≤ PPD < 6 mm |
50.7 (2.5) |
36.0 (5.0) |
14.7 (-29%) |
3.2 – 26.2 |
0.0087 |
| PPD ≥ 6 mm |
20§ |
11§ |
11|| (-55%) |
4 – 20¶ |
0.0010** |
| PIBI†† |
107.6 (5.8) |
64.3 (10.0) |
43.1 (-40%) |
19.5 – 66.7 |
0.00069 |
|
|
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| B. Tooth- adjusted inflammatory injury ‡‡ |
|||||
|
|
|||||
| PPD ≥ 4 mm |
3.1 (0.14) |
2. 1 (0.30) |
0.98 (-32%) |
0.28 – 1.61 |
0.0025 |
| 4 mm ≤ PPD < 6 mm |
2.0 (0.10) |
1.5 (0.20) |
0.48 (-25%) |
0.02 – 0.93 |
0.0274 |
| PPD ≥ 6 mm |
0.7§ |
0.4§ |
0.42|| (-56%) |
0.14 – 0.76¶ |
0.0025** |
| PIBI |
4.1 (0.22) |
2.7 (0.44) |
1.41 (-34%) |
0.41 – 2.42 |
0.0033 |
|
* Two-tailed P-values. †Number of periodontal pockets, mean (SE), unless otherwise indicated. ‡PPD is periodontal probing pocket depth. §Median. ||Estimate for difference of population medians calculated as described by Campbell and Gardner [22]. ¶Approximate 95% confidence interval (CI) for the difference in population medians calculated as described by Campbell and Gardner [22]. **P-value by Mann-Whitney U-test. ††PIBI is Periodontal Inflammatory Burden Index. ‡‡Number of periodontal pockets divided by number of teeth, mean (SE), unless otherwise indicated. | |||||
Lindy et al. BMC Oral Health 2008 8:16 doi:10.1186/1472-6831-8-16 |
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