Table 1

Antimicrobial Peptides in Saliva

Peptide

Origin

Role/comments

Major Oral Microbial Targets

References


Alpha-defensins HNP 1–4

Neutrophils, gingival sulcus, sites of inflammation, salivary duct cells

Antibacterial, antifungal, antiviral. Present in GCF

Candida albicans HIV S. mutans (poor)

(Raj et al., 2000; Zhang et al., 2002) [43, 44]

LL-37

Neutrophils, gingival sulcus, salivary glands and ducts

Primarily antibacterial

S. mutans F. nucleatum A. actinomycetemcomitans Capnocytophaga sputigena

(Ouhara et al., 2005; Tanaka et al., 2000) [17, 19]

Beta-defensins hBD1 hBD2 hBD3

Epithelia, salivary ducts

Antibacterial, antifungal, antiviral. Part of the protective barrier function of epithelium. Secreted

hBD1: Poor antibacterial hBD2, hBD3: S. mutans S. sanguis F. nucleatum P. gingivalis Candida albicans HIV

(Joly et al., 2004; Maisetta et al., 2003; Quinones-Mateu et al., 2003)[15, 20, 18]

Histatins

Salivary glands/ducts

Antifungal

Candida albicans

(Oppenheim et al., 1988) [6]


Dale et al. BMC Oral Health 2006 6(Suppl 1):S13   doi:10.1186/1472-6831-6-S1-S13

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