Table 3

Data of study populations and control groups in the studies included in the review
First author, year of publication Study population Control group
Al-Hashimi 1998 [31] 43 subjects: 39 age/gender/race matched healthy control subjects
−38 with pSSa
−5 with sSSb
Age and gender not stated
Almståhl 2003 [32] 39 subjects: 12 control subjects
−9 subjects with history of head and neck radiation (10 females/2 males) with normal salivary secretion rates Mean age 54 yrs
(2 females/8 malesc)
Mean age 55 yrs
−10 subjects with pSS
(10 females)
Mean age 57 yrs
−10 subjects treated with neuroleptic injections
(4 females/6 males)
Mean age 44 yrs
–10 subjects with hyposalivation due to medication or unknown origin
(9 females/1 male)
Mean age 54 yrs
El-Miedany 1999 [33] 25 subjects: 15 healthy age-matched controls
−15 with pSS Mean age 50 yrs
−10 with sSS 10 younger controls
(20 females/5 males) Mean age 26.2 yrs
Mean age 48 yrs Gender not stated
Håkansson 1994 [34] 17 subjects with pSS (15 females/2 males) 30 subjects with symptoms of dry mouth and/or eyes
Mean age 63 yrs (21 females/9 males)
Mean age 69 yrs
12 subjects without symptoms of dry mouth and/or eyes
(6 females/6 males)
Mean age 68 yrs
Hay 1998 [35] 341 subjects:
−189 females
Age (median) 49 yrs
−152 males
Age (median) 46 yrs
First author, year of publication Study population Control group
Kalk 2001 [36] 100 consecutive subjects: 36 healthy subjects
−33 with pSS (20 females/16 males)
(30 females/3 males) Mean age 39 yrs
Mean age 51 yrs
−25 with sSS
(21 females/4 males)
Mean age 54 yrs
−42 tested negative for SS
(40 females/2 males)
Mean age 55 yrs
Kalk 2002 [37] 20 subjects: 100 subjects (from previous study reported above-see study population)
−2 with pSS
−5 with sSS
(6 females/1 male)
Mean age 62 yrs
−13 non-SS
(13 females)
Mean age 55 yrs
Kanehira 2009 [38] 9 subjects with complaints of decreased salivary flow rate 31 healthy subjects
Age and gender reported for all included subjects
(22 females/19 males)
Mean age 48.8 yrs
Kohn 1992 [39] 22 subjects: 33 healthy volunteers
−19 with pSS (20 females/13 males)
−1 with sSS Mean age 54.4 yrs
−2 with idiopathic xerostomia
(17 females/5 males)
Mean age 52.2 yrs
Lee 2002 [40] 20 subjects with dry mouth 20 age/gender matched healthy control subjects
(unstimulated whole saliva flow rate <0.15 ml/min) (18 females/2 males)
(18 females/2 males) Mean age 42.6 yrs
Mean age 43.6 yrs
First author, year of publication Study population Control group
López-Jornet 2006 [41] 92 subjects: 70 healthy volunteers
−61 with pSS or sSS (35 females/35 males)
(50 females/11 males) Mean age 40.53 yrs
Mean age 57.08 yrs
−31 displaying symptoms of oral dryness from different causes
(29 females/2 males)
Mean age 52.52 yrs
Navazesh 1992 [42] A total of 71 subjects were included. Unclear
Approx. half with salivary gland hypofunction, defined as unstimulated whole salivary flow rate ≤0.20 ml/min Approx. half of the total number of included subjects. Individuals with normal salivary flow rates.
(48 females/23 males)
Mean age 52 yrs
Pedersen 1999 [43] 16 subjects: 14 healthy volunteers
(14 females/2 males) meeting the 1993 European classification for pSS. (13 females/1 male)
Mean age unclear Mean age 50 yrs
13 healthy volunteers
(12 females/1 male)
Mean age 24 yrs
Pennec 1993 [44] 72 consecutive subjects: 14 healthy subjects
- 40 subjects with pSS Mean age 64.7 yrs
−16 subjects with sSS Gender not stated
−16 subjects with connective tissue disease but no evidence of sSS
(70 females/2males)
Mean age 59.4 yrs
Sánchez-Guerrero 2002 [45] 90 subjects: 152 healthy subjects
−30 subjects with pSS (106 females/46 males)
(29 females/1 male) Mean age 35.2 yrs
Mean age 50.6 yrs
−60 subjects with CTDs without SS
(50 females/10 males)
Mean age 37.4 yrs
First author, year of publication Study population Control group
Sreebny 1988 [4] 151 subjects with reported dry mouth 372 subjects without reported dry mouth
(109 females/42 males) (219 females/159 males)
Age range 18–55+ Age range 18–55+
Wolff 1998 [46] 50 subjects: 25 subjects with no perception of dry mouth and no medication with resting salivary flow rates > 1.0 ml/min
−25 subjects with complaints of ‘dry mouth’ due to medication, with resting salivary flow rates ≤0.1 ml/min (15 females/10 males) Mean age 44
(20 females/5 males)
Mean age 48.5
−25 subjects with complaints of ‘dry mouth’ due to medication, with resting salivary flow rates > 0.1 ml/min
(18/females/7 males)
Mean age 49.2
Wolff 2002 [47] 27 subjects with complaints of dry mouth 32 healthy subjects
Age and gender not stated Age and gender not stated

a pSS = primary Sjögren’s syndrome.

b sSS = secondary Sjögren’s syndrome.

c Female/male ratio according to table in original study.

Löfgren et al.

Löfgren et al. BMC Oral Health 2012 12:29   doi:10.1186/1472-6831-12-29

Open Data