Table 4

Effects of glucagon-like peptide 1 before and after 5-day studies. Effects of vehicle at breakfast and effects of 0.63 μg/kg GLP-1 at breakfast on the day before and on the day after 5-day studies with GLP-1 or with vehicle in paired studies in eight volunteers with type 1 diabetes with no endogenous insulin secretion. Time-averaged incremental values (area under the curve divided by time) (AUC) for plasma glucose through three hours and for plasma pancreatic polypeptide from 0 to 30 min (HPP), mean ± SE, were higher for tests with vehicle at breakfast than for tests with GLP-1 at breakfast, ANOVA, repeated measures, P <.05. Mean AUC values for glucose and HPP did not differ for tests with GLP-1 at breakfast.

Test

Glucose mmol/l

HPP pmol/l

Vehicle at breakfast

5.3 ± 0.9

14 ± 3.0

5-day study with GLP-1:

GLP-1 at breakfast before treatment

3.4 ± 0.6

-2.3 ± 5.4

GLP-1 at breakfast after treatment

2.5 ± 0.8

1.4 ± 4.9

5-day study with vehicle:

GLP-1 at breakfast before treatment

3.5 ± 0.7

1.1 ± 3.1

GLP-1 at breakfast after treatment

2.0 ± 0.8

-1.6 ± 3.1

Behme et al. BMC Endocrine Disorders 2003 3:3   doi:10.1186/1472-6823-3-3