Reciprocal relationship between renal-vascular tissue-RAS activity and the renal-vascular response to angiotensin II. A blunted response to angiotensin II reflects a high level of local, endogenous, renal-vascular tissue-RAS activity (the smaller the decline in renal plasma flow in response to an infusion of angiotensin II, the greater the activity of the local renal-vascular tissue-RAS). Conversely, a robust response to angiotensin II is observed when tissue-RAS activity is low.
Brown et al. BMC Endocrine Disorders 2013 13:33 doi:10.1186/1472-6823-13-33