Table 4 |
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|
Retinal Lesions and TCF7L2 rs7903146 genotype by hypertension or diabetes status in Caucasians |
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|
With Hypertension |
Without Hypertension |
With Diabetes |
Without Diabetes |
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|
|
|
|
|
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|
Retinal Lesion |
n |
No. with Lesion (%) |
OR (95% CI)a |
n |
No. with Lesion (%) |
OR (95% CI)a |
n |
No. with Lesion (%) |
OR (95% CI)a |
n |
No. with Lesion (%) |
OR (95% CI)a |
|
|
|
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|
AV nicking |
CC |
1595 |
280 (17.55) |
1.00 |
2462 |
305 (12.39) |
1.00 |
525 |
89 (16.95) |
1.00 |
3533 |
496 (14.04) |
1.00 |
|
|
|||||||||||||
|
CT |
1297 |
222 (17.12) |
1.18 (1.02, 1.36) |
1989 |
211 (10.61) |
0.91 (0.78, 1.05) |
525 |
88 (16.76) |
0.99 (0.78, 1.26) |
2761 |
345 (12.50) |
1.04 (0.92, 1.16) |
|
|
|
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|
TT |
259 |
60 (23.17) |
1.39 (1.04, 1.86) |
430 |
46 (10.70) |
0.83 (0.61, 1.11) |
134 |
21 (15.67) |
0.98 (0.61, 1.58) |
555 |
85 (15.32) |
1.07 (0.85, 1.35) |
|
|
|
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|
P valueb |
0.03 |
0.21 |
0.94 |
0.56 |
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|
|
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|
Focal arteriolar narrowing |
CC |
1584 |
330 (20.83) |
1.00 |
2456 |
268 (10.91) |
1.00 |
519 |
88 (16.96) |
1.00 |
3522 |
510 (14.48) |
1.00 |
|
|
|||||||||||||
|
CT |
1290 |
320 (24.81) |
1.25 (1.09, 1.44) |
1978 |
223 (11.27) |
0.96 (0.82, 1.12) |
526 |
91 (17.30) |
0.85 (0.65, 1.11) |
2742 |
452 (16.48) |
1.18 (1.06, 1.32) |
|
|
|
|||||||||||||
|
TT |
259 |
67 (25.87) |
1.56 (1.18, 2.06) |
429 |
37 (8.62) |
0.92 (0.68, 1.25) |
136 |
15 (11.03) |
0.73 (0.42, 1.24) |
552 |
89 (16.12) |
1.40 (1.12, 1.75) |
|
|
|
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|
P valueb |
0.002 |
0.59 |
0.24 |
0.003 |
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|
|
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|
Retinopathy |
CC |
1612 |
136 (8.44) |
1.00 |
2492 |
100 (4.01) |
1.00 |
534 |
78 (14.61) |
1.00 |
3571 |
158 (4.42) |
1.00 |
|
|
|||||||||||||
|
CT |
1311 |
112 (8.54) |
1.04 (0.85, 1.26) |
2010 |
93 (4.63) |
1.12 (0.90, 1.39) |
536 |
76 (14.18) |
1.05 (0.82, 1.34) |
2785 |
129 (4.63) |
1.01 (0.84, 1.22) |
|
|
|
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|
TT |
262 |
23 (8.78) |
1.08 (0.73, 1.60) |
433 |
22 (5.08) |
1.26 (0.81, 1.94) |
136 |
23 (16.91) |
1.10 (0.67, 1.8) |
559 |
22 (3.94) |
1.02 (0.70, 1.48) |
|
|
|
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|
P valueb |
0.71 |
0.31 |
0.71 |
0.91 |
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|
|
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|
Abbreviations: AV, arteriovenous; CI, confidence interval; OR, odds ratio. aAdjusted for age, study center, gender, current smoking (yes/no), obesity, total serum cholesterol, total serum triglycerides, mean arterial blood pressure, hypertension (when stratified by diabetes), and antihypertensive medication; bP value for OR in the log additive genetic model. |
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|
Yan et al. BMC Endocrine Disorders 2010 10:9 doi:10.1186/1472-6823-10-9 |
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