Figure 7.

Some of the residues participating in indirect disordering of the HBN in B-RAF^WT. A close look at the conformation of the major catalytic residues, the DFG motif and the P-loop residues participating in the disordering of the identified hydrogen bond network in the unbounded B-RAF^WT after 15 ns of simulation time. The dotted lines and the adjacent values present the H-bonds and their distances.