Additional file 4.
Evolutionary dynamics of disulphides in the alpha/beta hydrolase serine carboxypeptidase-like family (SCOP code: c.69.1.5). Three superimposable members from this family are featured and which display one highly conserved disulphide (arrow). In (a) is featured a representative (SCOP domain: d1ac5_; PDB: 1ac5) from the serine carboxypeptidase II type and which displays two non-conserved disulphides. In (b) is featured a representative (SCOP domain: d1cpya_; PDB: 1cpy) from the human carboxypeptidase L type which display in addition to the conserved disulphide, four specific disulphides. In (c) is featured a representative from the human protective protein group which display in addition to the conserved disulphide, three specific disulphides.
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Thangudu et al. BMC Structural Biology 2008 8:55 doi:10.1186/1472-6807-8-55