Additional file 3.

Evolutionary dynamics of disulphides in the alpha/beta hydrolase actetylcholinesterase-like family (SCOP family code: c.69.1.1). Three highly superimposable members from this family are featured. In (a) is featured a representative (SCOP domain: d2bce__; PDB code: 2bce) from the cholesterol esterase and carboxyesterase types which display two highly conserved disulphides. In (b) is featured a representative (SCOP domain: d1dx4a_; PDB code: 1dx4) from the acetylcholinesterase type which display in addition to the two conserved disulphide, a third specific disulphide (arrow). In (c) is featured a representative from the paranitrobenzyl esterases group which do not feature any disulphide though two cysteines which are topologically equivalent to one highly conserved disulphide is present in the molecule.

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Thangudu et al. BMC Structural Biology 2008 8:55   doi:10.1186/1472-6807-8-55