Giant and dwarf domains of the SH3 domain like superfamily (a) [1i1ja(1–106)] and (b) [1gcqa-(158–213)]) show additional structures near the ligand-binding site. Structural superposition of the domain superfamily members (c) shows an appreciable conservation of the core structures (in yellow). (d) Structview representation of the alignment of different domain members of the protein superfamily shows a well conserved core involving β-strands and indels acquiring secondary structure in the giant domain.
Sandhya et al. BMC Structural Biology 2008 8:28 doi:10.1186/1472-6807-8-28