Figure 7.

Detail from the overlay of Mip^77–213 and FKBP12 in complex with rapamycin. Solution structure of the Mip-rapamycin complex is shown in blue and the crystal structure of the FKBP12-rapamycin complex in magenta. In FKBP12, F-48 does not directly contribute to binding of rapamycin. Its analogue in Mip, F-153, takes over the function of F-46 in FKBP12, because residue 151 is alanine in Mip.