Table 7

Spectrum of mutations in turns and bendsa

Amino acid

Original residues

Expected residues

χ2

P value

Mutant residues

Expected residues

χ2

P value


A

20

24

0.79

3.73E-01

21

28

1.85

1.74E-01

C

9

7

0.97

3.26E-01

22

16

1.86

1.72E-01

D

30

35

0.70

4.04E-01

27

19

3.56

5.92E-02

E

14

27

6.28**

1.22E-02

25

16

4.43*

3.54E-02

F

10

16

2.13

1.45E-01

16

19

0.42

5.16E-01

G

128

72

43.23***

4.87E-11

22

27

0.94

3.32E-01

H

17

13

1.12

2.91E-01

18

19

0.04

8.51E-01

I

8

12

1.20

2.73E-01

10

25

8.75**

3.10E-03

K

10

28

11.80***

5.92E-04

17

16

0.02

8.95E-01

L

24

30

1.27

2.60E-01

20

39

9.12**

2.53E-03

M

10

8

0.67

4.13E-01

8

11

0.63

4.27E-01

N

19

26

1.72

1.90E-01

12

19

2.47

1.16E-01

P

24

29

1.02

3.12E-01

33

28

0.81

3.69E-01

Q

7

21

9.71**

1.84E-03

14

16

0.37

5.44E-01

R

69

26

70.17***

5.44E-17

63

40

13.25***

2.73E-04

S

27

34

1.27

2.59E-01

36

44

1.30

2.55E-01

T

16

20

0.68

4.09E-01

22

28

1.37

2.41E-01

V

7

17

6.05**

1.39E-02

42

28

6.72**

9.52E-03

W

4

5

0.07

7.92E-01

16

8

7.33**

6.78E-03

Y

8

11

1.02

3.13E-01

17

14

0.59

4.42E-01


Sum

461

461

461

461


aχ2-numbers in italics indicate underrepresentation and numbers in bold overrepresentation compared to random distribution based on amino acid frequencies. The results of the χ2 are shown with significance level: * P < 0.05; ** P < 0.01; *** P < 0.001.

Khan and Vihinen BMC Structural Biology 2007 7:56   doi:10.1186/1472-6807-7-56

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