Table 7 |
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|
Spectrum of mutations in turns and bendsa |
||||||||
|
Amino acid |
Original residues |
Expected residues |
χ2 |
P value |
Mutant residues |
Expected residues |
χ2 |
P value |
|
|
||||||||
|
A |
20 |
24 |
0.79 |
3.73E-01 |
21 |
28 |
1.85 |
1.74E-01 |
|
C |
9 |
7 |
0.97 |
3.26E-01 |
22 |
16 |
1.86 |
1.72E-01 |
|
D |
30 |
35 |
0.70 |
4.04E-01 |
27 |
19 |
3.56 |
5.92E-02 |
|
E |
14 |
27 |
6.28** |
1.22E-02 |
25 |
16 |
4.43* |
3.54E-02 |
|
F |
10 |
16 |
2.13 |
1.45E-01 |
16 |
19 |
0.42 |
5.16E-01 |
|
G |
128 |
72 |
43.23*** |
4.87E-11 |
22 |
27 |
0.94 |
3.32E-01 |
|
H |
17 |
13 |
1.12 |
2.91E-01 |
18 |
19 |
0.04 |
8.51E-01 |
|
I |
8 |
12 |
1.20 |
2.73E-01 |
10 |
25 |
8.75** |
3.10E-03 |
|
K |
10 |
28 |
11.80*** |
5.92E-04 |
17 |
16 |
0.02 |
8.95E-01 |
|
L |
24 |
30 |
1.27 |
2.60E-01 |
20 |
39 |
9.12** |
2.53E-03 |
|
M |
10 |
8 |
0.67 |
4.13E-01 |
8 |
11 |
0.63 |
4.27E-01 |
|
N |
19 |
26 |
1.72 |
1.90E-01 |
12 |
19 |
2.47 |
1.16E-01 |
|
P |
24 |
29 |
1.02 |
3.12E-01 |
33 |
28 |
0.81 |
3.69E-01 |
|
Q |
7 |
21 |
9.71** |
1.84E-03 |
14 |
16 |
0.37 |
5.44E-01 |
|
R |
69 |
26 |
70.17*** |
5.44E-17 |
63 |
40 |
13.25*** |
2.73E-04 |
|
S |
27 |
34 |
1.27 |
2.59E-01 |
36 |
44 |
1.30 |
2.55E-01 |
|
T |
16 |
20 |
0.68 |
4.09E-01 |
22 |
28 |
1.37 |
2.41E-01 |
|
V |
7 |
17 |
6.05** |
1.39E-02 |
42 |
28 |
6.72** |
9.52E-03 |
|
W |
4 |
5 |
0.07 |
7.92E-01 |
16 |
8 |
7.33** |
6.78E-03 |
|
Y |
8 |
11 |
1.02 |
3.13E-01 |
17 |
14 |
0.59 |
4.42E-01 |
|
|
||||||||
|
Sum |
461 |
461 |
461 |
461 |
||||
|
|
||||||||
|
aχ2-numbers in italics indicate underrepresentation and numbers in bold overrepresentation compared to random distribution based on amino acid frequencies. The results of the χ2 are shown with significance level: * P < 0.05; ** P < 0.01; *** P < 0.001. |
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|
Khan and Vihinen BMC Structural Biology 2007 7:56 doi:10.1186/1472-6807-7-56 |
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