Table 11

Spectrum of mutations in turns and bends in amino acid groups^a

Amino acid group

Original residues

Expected residues

χ²

P value

Mutant residues

Expected residues

χ²

P value

Hydrophobic

80

105

6.02**

1.42E-02

151

160

0.50

4.80E-01

Positively charged

44

62

5.21*

2.24E-02

52

35

7.92**

4.88E-03

Negatively charged

96

68

11.94***

5.48E-04

98

75

6.87**

8.78E-03

Conformational

152

102

24.95***

5.90E-07

55

55

0.00

9.71E-01

Polar

53

81

9.44**

2.12E-03

62

79

3.58

5.85E-02

A+T

36

44

1.48

2.24E-01

43

56

3.20

7.34E-02

Sum

461

461

461

461

^aχ²-numbers in italics indicate underrepresentation and numbers in bold overrepresentation compared to random distribution based on amino acid frequencies. The results of the χ² are shown with significance level: * P < 0.05; ** P < 0.01; *** P < 0.001.

Khan and Vihinen BMC Structural Biology 2007 7:56   doi:10.1186/1472-6807-7-56